ArticleScientific reports2025
Chemical profiling by LC-MS/MS and GC-MS and biological activity assessment of different extracts of Portulaca oleracea through in-vitro and in-silico approaches.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Unveiling the antidiabetic, anti-inflammatory and anti-hemolytic activities of Raphanus sativus leaves through in-vitro and in-silico studies.Scientific reports · 2026Article
- ADME/drug-likeness and functional properties of Punica granatum seeds supported with molecular docking, GC-MS and LC-MS/MS analysis.Scientific reports · 2026Article
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Authors and funding
4 authors.
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Abstract
In this study, the phenolic compound profile and essential oil composition of Portulaca oleracea L. collected from the Bulancak (Giresun) region of Türkiye were investigated in detail by LC-MS/MS and GC-MS techniques. The obtained data were then correlated with multifaceted biological activity tests and in-silico molecular modelling. In the scope of the study, the anti-diabetic (inhibition of α-amylase and α-glucosidase), anti-inflammatory (inhibition of protein denaturation) and anti-hemolytic effects were evaluated in conjunction with the chemical composition data. The results of the LC-MS/MS analysis indicate that p-coumaric acid is the predominant phenolic, with a concentration of 1228.10 mg/kg. The presence of other phenolics was also detected, including vanillin (5.12 mg/kg), caffeic acid (2.75 mg/kg), sesamol (1.87 mg/kg) and protocatechuic aldehyde (1.75 mg/kg). In the GC-MS analysis, hexahydrofarnesyl acetone was the most abundant component, accounting for 58.89% of the total. Subsequent analysis identified dillapiole (16.80%), myristicin (8.95%), and β-ionone (6.31%) as the active constituents. In the anti-diabetic activity test, the IC
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