ArticleScientific reports2025
An ultrasound-guided biopsy technique for obtaining supraclavicular brown fat biopsies and preadipocytes.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Deciphering the Presence of Active Interscapular Brown Adipose Tissue in Humans.Acta physiologica (Oxford, England) · 2026Review
- ACLY Safeguards Copper Homeostasis to Sustain Brown Adipose Tissue Thermogenesis and Restrain Diet-Induced Obesity.Research (Washington, D.C.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown adipose tissue (BAT) is considered a potential therapeutic target for obesity and other metabolic diseases, due to its ability to convert glucose and fatty acids to heat. However, studying activated human BAT in vivo poses challenges due to its intricate anatomical positioning e.g. in the supraclavicular area. We present an ultrasound-guided biopsy technique for collecting small biopsies from the supraclavicular area and procedures for RNA extraction and adipose progenitor cell isolation from said biopsies. We show that it is possible to extract sufficient RNA for qPCR analysis and isolate adipose progenitor cells with differentiation capacity from the small biopsies. The success rate of the procedures was, however, low, with only few of the isolated progenitors being able to successfully differentiate, and most samples and cell cultures not showing a clear BAT profile. In the manuscript we discuss possible methodological refinements to yield a higher success rate. We thus present a proof of concept and a first step towards a new method for obtaining and studying human BAT, which would enable the conduction of clinical intervention studies of BAT biology in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.