ArticleScientific reports2025
A standardized and reproducible rodent model of esophagogastric anastomosis healing following esophageal transection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental animal models are indispensable for investigating disease mechanisms and therapeutic strategies. Esophageal resection remains the only curative treatment for esophageal cancer, but disruption of the esophagogastric anastomosis is associated with high morbidity and mortality. To better understand anastomotic healing and related complications, a simple and reproducible rodent model is required. In this study, we developed a novel, reliable technique for establishing esophagogastric anastomosis in rats. Hand-sewn end-to-end anastomoses were performed following esophageal dissection, with a 4-mm silicone catheter placed from the gastrotomy into the distal esophagus to facilitate suturing. Anastomoses were constructed with continuous nonabsorbable sutures in 10 male Sprague-Dawley rats. Histological evaluation of healing was performed 5 days postoperatively. Normal anastomotic healing was observed in 9 animals, while 1 rat developed leakage with sepsis and died shortly after revision on postoperative day 3. Histology confirmed physiological healing in successful cases. This study presents a simple, reproducible rat model of esophagogastric anastomosis healing, offering a valuable platform for bridging the gap between basic research and clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.