ArticleNature communications2025
Cross-regional real-time visualization of systemic physiology and dynamics with 3D panoramic photoacoustic computed tomography (3D-PanoPACT).
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions.Photoacoustics · 2026Review
- Robust automated three-dimensional speed-of-sound compensation for hemispherical photoacoustic computed tomography.Photoacoustics · 2026Article
- Phase-aberration-corrected coherence factor beamforming for photoacoustic computed tomography.Journal of biomedical optics · 2026Article
- Review
- Robust hybrid feature-driven on-the-fly mapping enables freehand 3D panoramic photoacoustic angiography.Light, science & applications · 2026Article
- Data-driven super-resolution optoacoustic imaging via physically encoded signal acquisition.Research square · 2026Article
- Photoacoustic Tomography Tracks Vascular Remodeling and Functional Recovery in Liver Regeneration.BME frontiers · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Non-invasive systemic visualization is crucial in biomedical research. Photoacoustic imaging transcends the optical scattering limitations, capturing optical absorption from deep tissue at high resolution. Nevertheless, the full exploitation of its physical advantages faces challenges due to unsatisfactory field of view (FOV), spatiotemporal resolution, and imaging quality. Here, we demonstrate that 3D panoramic photoacoustic computed tomography (3D-PanoPACT) mitigates these limitations by combining dynamical and functional contrasts, high spatiotemporal resolution, and broad three-dimensional FOV, allowing for visualizing cross-regional dynamics from organ to whole-body level. Leveraging its single-pulse-volumetric imaging capability, 3D-PanoPACT imaged the whole liver at 25 Hz, facilitating the extraction of arterial networks. Real-time monitoring of whole-brain vasculatures and functional hemodynamics induced by pharmacological action and physical stimulation was demonstrated, especially in the Circle of Willis. The dynamic visualization of the whole trunk at 10 Hz further substantiates its capacity for systemic imaging. We tracked the metabolic pathways of a small-molecule probe across multiple organs using 3D-PanoPACT, highlighting its value in whole-body, cross-regional dynamic studies. 3D-PanoPACT, being a potent novel imaging tool, exhibits substantial potential for advancing biotechnology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.