Evidence map›Paper›PMID 41253774›Full record

ArticleNature communications2025

Engineering hormonal crosstalk to enhance serotonin/melatonin levels in rice.

Yuanjiang Cui, Xinyue Hou, An Wang, Zhengji Shao, Chaoqing Ding, Wei Xie, Longbiao Guo, Guangheng Zhang, Li Zhu, Jiang Hu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuanjiang Cui *State Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Xinyue Hou *State Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
An Wang *State Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Zhengji ShaoState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Chaoqing DingState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Wei XieState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Longbiao GuoState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.ORCID http://orcid.org/0000-0003-1016-049X
Guangheng ZhangState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Li ZhuState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Jiang HuState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Zhenyu GaoState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Guojun DongState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Qiang ZhangState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Qing LiState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.ORCID http://orcid.org/0000-0001-7010-7776
Lan ShenState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Min HuState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Qian QianState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China. qianqian188@hotmail.com.ORCID http://orcid.org/0000-0002-0349-4937
Deyong RenState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China. rendeyong616@163.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32188102
6 · The paper itself

Abstract

Enhancing crop nutritional value is important for advancing sustainable human health. Serotonin (5-HT) and its derivative melatonin (MT) are versatile physiological regulators, known for their roles in sleep enhancement, anxiety reduction, and immune modulation. Here, we discover that abscisic acid (ABA) induces the biosynthesis of 5-HT. This induction depends on the regulation by Abscisic Acid Insensitive 5 (ABI5) and negatively feedback-controlled by the possible PP2Cs-SAPK2-ABI5 interaction. This feedback regulation likely involves ABA signaling crosstalk. Specifically, 5-HT modulates ABA-mediated PP2C activity, thereby influencing the SAPK2 phosphorylation. This modulation subsequently reduces the phosphorylation and transcriptional activity of ABI5, ultimately attenuating the ABA signaling cascade. The T162 and T283 residues of SAPK2 contribute to modulating ABI5 phosphorylation. Based on the crosstalk between ABA and 5-HT, we develop several rice lines with enhanced 5-HT/MT levels without compromising grain yield. These engineered rice lines hold promise for improving rice's nutritional value and promoting the production of health-beneficial foods.

Indexed as

MelatoninOryzaPlant Growth RegulatorsSerotoninAbscisic AcidGene Expression Regulation, PlantPhosphorylationPlant ProteinsPlants, Genetically ModifiedSignal TransductionAbscisic AcidMelatoninPlant Growth RegulatorsPlant ProteinsSerotonin

Identifiers

PMID41253774
PMCPMC12627605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.