Evidence map›Paper›PMID 41253754›Full record

ArticleNature communications2025

Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb.

Xinli Qu, Ehsan Razmara, Ashiq Khader C, Chee Ho H'ng, Kailash K Vinu, Luciano G Martelotto, Maia Zethoven, Fernando J Rossello, Shanika L Amarasinghe, David R Powell and 1 more

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In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinli Qu *Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia.
Ehsan Razmara *Australian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia.
Ashiq Khader CDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Chee Ho H'ngAustralian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia.
Kailash K VinuAustralian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia.
Luciano G MartelottoUniversity of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-9625-1183
Maia ZethovenPeter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-6528-891X
Fernando J RosselloMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, Australia.
Shanika L AmarasingheAustralian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-2229-8106
David R PowellMonash Genomics and Bioinformatics Platform, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-6639-6250
Alberto Rosello-DiezAustralian Regenerative Medicine Institute, Monash University, Melbourne, VIC, Australia. ar2204@cam.ac.uk.ORCID http://orcid.org/0000-0002-5550-9846

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growth-plate cartilage of the developing long bones is a well-known system of spatially segregated stem/progenitor, transient amplifying and terminally differentiated cells. However, the regulation of the number and activity of long-lived cartilage progenitors (LLCPs) is poorly understood, despite its relevance for understanding human-height variation, the evolution of limb size and proportions and the aetiology of skeletal growth disorders. Moreover, whether their behaviour can adapt to developmental perturbations, generating robustness, has not been explored. Here, we show that Gli1

Indexed as

ChondrocytesChondrogenesisExtremitiesStem CellsStromal CellsZinc Finger Protein GLI1AnimalsCartilageCell DifferentiationFemaleFetusGrowth PlateMiceMice, Inbred C57BLMice, TransgenicReceptor, Platelet-Derived Growth Factor alphaGli1 protein, mouseReceptor, Platelet-Derived Growth Factor alphaZinc Finger Protein GLI1

Identifiers

PMID41253754
PMCPMC12627582

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.