Evidence map›Paper›PMID 41253702›Full record

Trial reportAddiction biology2025

No Effects of rTMS on Performance Monitoring and Attentional Bias in Patients With Alcohol Use Disorder: A Pilot Study.

Maarten Belgers, Wiebren Markus, Federico Grasso, Martijn Arns, Philip Van Eijndhoven, Arnt Schellekens

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01973127 (Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01973127 naunknown statusnot on this map

Repetitive Transcranial Magnetic Stimulation (rTMS) in Alcohol Dependent Patients: a Mechanistic Study.

TypeinterventionalSponsorIrisZorgRan2014 to 2016Enrolled30ConditionsAlcohol AddictionArmsVerum rTMS, Sham rTMS
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maarten BelgersIrisZorg, Center for Addiction Care and Sheltered Housing, Arnhem, the Netherlands.
Wiebren MarkusIrisZorg, Center for Addiction Care and Sheltered Housing, Arnhem, the Netherlands.
Federico GrassoCooperativa Sociale P.G. Frassati, Turin, Italy.
Martijn ArnsBrainclinics Foundation, Nijmegen, the Netherlands.
Philip Van EijndhovenDepartment of Psychiatry, Radboud University Medical Center (Radboudumc), Nijmegen, the Netherlands.
Arnt SchellekensDepartment of Psychiatry, Radboud University Medical Center (Radboudumc), Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) presents a promising approach for treating patients with alcohol use disorder (AUD). However, its neuropsychological working mechanisms are to be elucidated. Therefore, we investigated the effect of rTMS treatment on event-related potentials (ERPs) evoked by a flanker task and a passive picture task using electro-encephalography, in 30 recently detoxified patients. Participants were randomly assigned to receive either 10 sessions of rTMS or sham rTMS. Measurements were made at baseline, and after 5 and 10 treatments. The results revealed no significant effect of rTMS on any of the assessed ERPs (N100, N200, and P300). These findings suggest that high-frequency rTMS applied over the right dlPFC, in addition to treatment as usual (TAU), does not impact performance monitoring or attentional bias in recently detoxified patients with AUD. Bayesian analyses did suggest a potential effect of rTMS on N100 amplitude at frontal electrode FZ. These preliminary findings warrant further study of the effects of rTMS on ERP outcomes in AUD patients, and exploration of ERPs related to performance monitoring and attentional bias as potential neuropsychological markers for the clinical effects of rTMS. However, other neuropsychological markers, like brain network connectivity, should also be explored. CLINICAL

trial registrationRegistered in a trial Register (ClinicalTrials.gov Identifier: NCT01973127)f.

Indexed as

AlcoholismAttentional BiasEvoked PotentialsTranscranial Magnetic StimulationAdultElectroencephalographyFemaleHumansMaleMiddle AgedPilot Projectsalcohol use disorderattentional biaselectroencephalogramevent‐related potentialneuromarkerperformance monitoringtranscranial magnetic stimulation

Identifiers

PMID41253702
PMCPMC12626745

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.