Evidence map›Paper›PMID 41253496›Full record

ArticleeNeuro2025

Ionotropic Glutamate Receptor Function in Interpeduncular Nucleus Is Modulated by Nicotine Exposure.

Yijin Yan, Brenton R Tucker, Andrew E Tapp, Leanne N Thomas, Dylan R Drenan, Ryan M Drenan

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yijin YanDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101.
Brenton R TuckerDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101.
Andrew E TappDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101.
Leanne N ThomasDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101.
Dylan R DrenanDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101.
Ryan M DrenanDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101 ryan.drenan@wfusm.edu.ORCID https://orcid.org/0000-0002-8141-8577

Funding

Identifying nicotine withdrawal mechanisms hidden within habenular complexityR01DA040626 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ryan Michael Drenan · 2016 to 2026
$4.0M
NIDA NIH HHS R01 DA040626
6 · The paper itself

Abstract

The medial habenula (MHb) and its main projection target, the interpeduncular nucleus (IPN), play an important role in mood/affect, anxiety, and the aversive experience associated with nicotine withdrawal. Given that MHb axons release glutamate onto IPN neurons, we investigated the expression and functional responses of ionotropic glutamate receptors (iGluRs) in neurons of the rostral IPN (IPR) in male rats. After confirming mRNA expression of

Indexed as

Interpeduncular NucleusNeuronsNicotineNicotinic AgonistsReceptors, AMPAAnimalsExcitatory Postsynaptic PotentialsGlutamic AcidMalePatch-Clamp TechniquesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateRNA, MessengerSelf AdministrationGlutamic AcidNicotineNicotinic AgonistsReceptors, AMPAReceptors, N-Methyl-D-AspartateRNA, Messengeraddictionglutamatenicotinereceptorself-administrationuncaging

Identifiers

PMID41253496
PMCPMC12668794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.