Evidence map›Paper›PMID 41253129›Full record

ArticleAmerican journal of speech-language pathology2026

Language Skills in Patients With Alexander Disease.

Debra Levin, Jordan Levin, Joshua Joung, Geraldine W Liu, Joseph Donaher, Walter Faig, Amy T Waldman

Abstract read
In one paragraph

Article in American journal of speech-language pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Debra LevinDepartment of Speech-Language Pathology, Center for Childhood Communication, Children's Hospital of Philadelphia, PA.ORCID 0009-0007-8420-9766
Jordan LevinDivision of Neurology, Children's Hospital of Philadelphia, PA.
Joshua JoungDivision of Neurology, Children's Hospital of Philadelphia, PA.
Geraldine W LiuDivision of Neurology, Children's Hospital of Philadelphia, PA.
Joseph DonaherDepartment of Speech-Language Pathology, Center for Childhood Communication, Children's Hospital of Philadelphia, PA.
Walter FaigBiostatistics and Data Management Core, Children's Hospital of Philadelphia, PA.
Amy T WaldmanDivision of Neurology, Children's Hospital of Philadelphia, PA.

Funding

Validation of the GMFC-MLDU54NS115052 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Laura Ann Adang, FLORIAN S EICHLER · 2019 to 2026
$14.3M
NINDS NIH HHS U54 NS115052
6 · The paper itself

Abstract

purposeThis study aimed to investigate the language skills of children with Alexander disease (AxD) and determine whether disease subtypes and/or age contributes to variability in language performance.

methodEighty-two participants with AxD, confirmed by

resultsThe mean PLS-5 Total Language Score (TLS) was 70.10 (

conclusionsCerebral patients demonstrated significant language deficits, whereas intermediate and bulbospinal subjects displayed stronger abilities, with deficits in some patients. These implications can be used to determine the functional impact of communication deficits and to provide accommodations and interventions in the treatment plans of patients with AxD.

Indexed as

Alexander DiseaseChild LanguageLanguage Development DisordersAdolescentAge FactorsChildChild, PreschoolFemaleHumansLanguage TestsMalePhenotype

Identifiers

PMID41253129
PMCPMC12805811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.