ArticleHormones and behavior2026
Appetitive maternal behavior in mice is resistant to perinatal chronic variable stress and perinatal chronic corticosterone treatment.
Article in Hormones and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026Review
- Chronic prenatal corticosterone exposure alters postpartum maternal behavior and shapes sex-specific offspring outcomes.Research square · 2026Article
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Authors and funding
6 authors.
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Abstract
Perinatal stress is a risk factor for emotional and cognitive disturbances in both caregivers and their infants. Here, we compared the impact of two stressors, perinatal chronic variable stress (CVS) and perinatal chronic corticosterone treatment (C-CORT), on maternal exploratory behavior, maternal caregiving, and hypothalamic neural activity. We stressed mouse dams with each paradigm for 13 days starting at gestational day 11 (GD11). We examined open field exploration behavior on day 12 of stress (or post-partum day 3, PP3) and pup-directed behavior on day 13 of stress (PP4). We collected brains and serum 30 min after pup exposure to study circulating maternal corticosterone and the expression of the immediate-early gene Fos in hypothalamic neuropeptidergic cell populations. We found that perinatal CVS reduced distance moved and increased immobility in the open field, suggestive of a depression-like phenotype, while perinatal C-CORT reduced time spent in the center of the open field, suggestive of an anxiety-like phenotype. Dams exposed to both stressors showed intact appetitive maternal behavior. Importantly, we found that CVS in mated, unpregnant females led to hypoactivity in the open field and significantly increased pup retrieval latency. Both stressors led to reduced Fos colocalization with corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus (PVH
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