Evidence map›Paper›PMID 41252780›Full record

ArticleTuberculosis (Edinburgh, Scotland)2025

Minimal immune cell subset differences in a cohort of close contacts of tuberculosis index cases.

Sudhasini Panda, Catherine Cheng, Naomi Hillery, Donald G Catanzaro, Nelly Ciobanu, Valeriu Crudu, Timothy Rodwell, Antonino Catanzaro, Julie G Burel, Bjoern Peters and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tuberculosis (Edinburgh, Scotland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sudhasini PandaCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Catherine ChengCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Naomi HilleryDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Donald G CatanzaroDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR, USA.
Nelly CiobanuPneumology Institute, Chisinau, Republic of Moldova.
Valeriu CruduPneumology Institute, Chisinau, Republic of Moldova.
Timothy RodwellDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Antonino CatanzaroDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Julie G BurelCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.
Bjoern PetersCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Cecilia S Lindestam ArlehamnCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark. Electronic address: cela@ssi.dk.

Funding

Large Scale T Cell Epitope Discovery: Proteome-wide characterization of T cell epitopes from Mycobacterium tuberculosis in vaccination and active infection75N93019C00067 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN · 2019 to 2023
$4.5M
Identifying individuals at risk of progression to active tuberculosisR01AI137681 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CATANZARO, ANTONINO, RODWELL, TIMOTHY CHARLES · 2018 to 2022
$3.7M
NIAID NIH HHS 75N93019C00067NIAID NIH HHS R01 AI137681
6 · The paper itself

Abstract

Understanding the perturbations in immune response across the spectrum of TB infection is still unclear. Here, we followed close contacts of pulmonary TB patients with serial QFT testing at 0, 3, 6, and 12 months, and stratified them into six subgroups: QFT-increasing (low/high), QFT-converters (QFT-to QFT+), QFT + stable, and QFT-individuals. Despite these distinct QFT trajectories, we observed minimal differences in immune cell frequencies, activation profiles, and T-helper subset distributions among QFT subgroups, suggesting limited immunological stratification based on QFT dynamics. Ex vivo immune phenotyping, including CD4, CD8, NKT cell frequencies, memory T-cell subsets, and activated T-cells (HLA-DR

Indexed as

Contact TracingMycobacterium tuberculosisT-Lymphocyte SubsetsTuberculosis, PulmonaryAdultBiomarkersFemaleHost-Pathogen InteractionsHumansImmunophenotypingInterferon-gammaInterferon-gamma Release TestsLymphocyte ActivationMaleMiddle AgedPredictive Value of TestsBiomarkersInterferon-gamma

Identifiers

PMID41252780
PMCPMC13373719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.