ArticleAging2025
Topography of small vessel cerebrovascular disease differentially impacts cognitive domains across cognitive syndromes.
Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Serum cystatin C levels are independently correlated with cognitive impairment in individuals with cerebral small vessel disease.Frontiers in neuroscience · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDementia in Asia, presents distinct neuropathological features, with White Matter Hyperintensities (WMH) emerging as critical indicators of small vessel disease. WMH, classified into Deep White Matter Hyperintensities (DWMH), Periventricular Hyperintensities (PVH), and Fazekas-Total, exhibit high prevalence in Asian populations. Although WMH are prevalent and recognized indicators of small vessel disease, the domain-specific cognitive impact of WMH location remains unclear. We hypothesized that examining both cognitively normal (CN) and mild cognitive impairment (MCI) groups separately would clarify whether WMH topography exerts distinct effects at different stages of cognitive decline.
methods430 participants were recruited, and a cross-sectional analysis performed. Eight domains of cognition were assessed: global cognition, learning/memory, language, executive function, attention, visuo-spatial, working memory, and processing speed. Correlation and stepwise regression (with False Discovery Rate correction) were performed. 217 participants were classified as Mild Cognitive Impairment (MCI) and 213 participants as Cognitively Normal (CN) as per National Institute on Aging-Alzheimer's Association criteria.
resultsIn CN participants, higher Fazekas-Total was associated with impaired attention ( DISCUSSION: This study demonstrates that WMH burden-particularly DWMH-exerts differential domain-specific effects in CN versus MCI populations, underscoring the importance of WMH topography in early cognitive changes. Our results suggest that evaluating DWMH separately from overall WMH may refine clinical assessments and mechanistic understanding of vascular contributions to cognitive impairment. Future research should target upstream pathophysiological processes underlying region-specific WMH to improve early detection and intervention strategies.
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