Evidence map›Paper›PMID 41252611›Full record

ReviewJournal of medicinal chemistry2025

What Do Oral Drugs Really Look Like? Dose Regimen, Pharmacokinetics, and Safety of Recently Approved Small-Molecule Oral Drugs.

Dean G Brown

Abstract readReview
In one paragraph

Review in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Misconceptions among medicinal chemists regarding ADME and PK optimization.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Dean G BrownJnana Therapeutics, One Design Center Pl Suite 19-400, Boston, Massachusetts 02210, United States.ORCID 0000-0002-7130-3928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An analysis of dose, dose frequency, human pharmacokinetics, and potential drug-drug interactions (DDI) was performed on small-molecule oral drugs approved by the FDA from 2020 to 2024 (

Indexed as

Small Molecule LibrariesAdministration, OralDose-Response Relationship, DrugDrug ApprovalDrug InteractionsHumansPharmaceutical PreparationsUnited StatesUnited States Food and Drug AdministrationPharmaceutical PreparationsSmall Molecule Libraries

Identifiers

PMID41252611
PMCPMC12670434

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.