Evidence map›Paper›PMID 41252595›Full record

ArticleJournal of the American Chemical Society2025

A Sterically Open Ruthenium-Based Photocage Activated by Red and Far-Red Light for a Wide Range of Drugs.

Yurii Husiev, Sina Katharina Götzfried, Matthijs L A Hakkennes, Daria Kotova, Isabelle Tutein Nolthenius, Corjan van de Griend, Andrew C Johns, Selda Abyar, Maxime A Siegler, Alexander Kornienko and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yurii HusievLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0003-3776-9844
Sina Katharina GötzfriedLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0003-4565-4326
Matthijs L A HakkennesLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0002-9285-7161
Daria KotovaLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Isabelle Tutein NoltheniusLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Corjan van de GriendLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Andrew C JohnsDepartment of Chemistry and Biochemistry, Texas State University, 601 University Dr., San Marcos, Texas 78666, United States.
Selda AbyarLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Maxime A SieglerDepartment of Chemistry, Johns Hopkins University, 3400 N Charles St., Baltimore, Maryland 21218, United States.ORCID 0000-0003-4165-7810
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University, 601 University Dr., San Marcos, Texas 78666, United States.ORCID 0000-0003-2041-7367
Sylvestre BonnetLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0002-5810-3657

Funding

Single Crystal X-ray Diffractometer with Microfocus Rotating Anode Source (Cu)S10OD030352 · OD · JOHNS HOPKINS UNIVERSITY · PI SIEGLER, MAXIME A · 2022 to 2022
$471k
NIH HHS S10 OD030352
6 · The paper itself

Abstract

Herein we report a novel ruthenium-based photocage for photoactivated chemotherapy (PACT) that can deliver a variety of experimental and clinically approved anticancer drugs using red and far-red light. The new caging moiety is based on the polypyridine pentadentate ligand

Indexed as

Antineoplastic AgentsCoordination ComplexesLightProdrugsRutheniumCell Line, TumorDrug Screening Assays, AntitumorHumansMolecular StructureRed LightAntineoplastic AgentsCoordination ComplexesProdrugsRuthenium

Identifiers

PMID41252595
PMCPMC12679631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.