ArticleJournal of cosmetic dermatology2025
Protective Effects of Exogenous Donkey Oil on Skin Healing Under Incisional Wound Damage.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Protective Effects of Exogenous Donkey Oil on Skin Healing Under Incisional Wound Damage.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThe identification of cosmetic ingredients that promote wound healing with minimal inflammation is urgently needed. Donkey oil (DO) is a promising candidate due to its nutritional richness and biosafety.
aimsThis study aimed to evaluate the efficacy of DO in promoting wound healing and to elucidate its underlying mechanisms of action.
methodsA murine incisional wound model was established. Wounds were treated with 12.5%, 25%, or 50% DO. Healing was assessed through phenotypic observation, H&E staining, quantification of inflammatory cytokines (IL-1α, IL-6, PGE2, and CCL2) and VEGF, transcriptome sequencing, and qPCR validation.
resultsTreatment with 25% and 50% DO significantly accelerated wound closure by 35.22% and 34.33%, respectively, and reduced inflammatory cell infiltration by 63.77% and 79.00%. Furthermore, DO preserved skin structural integrity, concurrently inhibited inflammatory cytokines increased VEGF levels, and reduced MMP-9. To explore the potential mechanism, transcriptome analysis identified 13 603 shared differentially expressed genes (DEGs). Subsequent GO and KEGG enrichment analyses indicated these DEGs were involved in key processes like actin cytoskeleton organization and pathways related to anti-infection and cell repair. Finally, qPCR confirmed the reversal of IL-6 and CCL2 expression and the upregulation of TGF-α.
conclusionsDO significantly promotes wound healing by modulating anti-inflammatory responses and enhancing tissue repair mechanisms, demonstrating its great potential as an effective cosmetic ingredient.
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Registered trials
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