Evidence map›Paper›PMID 41252548›Full record

ArticleJournal of cosmetic dermatology2025

Overexpression of miR-431-5p Inhibits the Development of Hypertrophic Scars by Negatively Regulating the Expression of ZEB1.

Yaqing Liu, Tonghao Yao, Xiaolin Miao, Suwen Zhang, Junjie Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yaqing LiuMedical Services Department, Shanghai Changzheng Hospital, Shanghai, China.
Tonghao YaoDepartment of Plastic and Aesthetic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiaolin MiaoDepartment of Dermatology and Venereology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Suwen ZhangDepartment of Plastic Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, China.ORCID https://orcid.org/0009-0005-0744-3773
Junjie LiaoDermatology Department, Wenzhou Ouhai District People's Hospital, Wenzhou, China.ORCID https://orcid.org/0009-0005-3993-9052

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe exact mechanism underlying hypertrophic scar (HS) remains elusive at present.

aimsThis study aimed to investigate the potential regulatory mechanism of microRNA-431-5p in HS. PATIENTS/

methods100 HS patients were recruited in this study. The relative expression of miR-431-5p, ZEB1, and α-SMA was quantified using RT-qPCR. Cell proliferation was assessed via the CCK-8 assay. Cell migration was evaluated using the Transwell. Cell apoptosis was determined by flow cytometry. Inflammatory factors' levels were measured through ELISA (Enzyme-Linked Immunosorbent Assay). The targeting regulatory relationship was confirmed by the dual-luciferase assay.

resultsmiR-431-5p was significantly reduced in HS tissues. Overexpression of miR-431-5p markedly suppressed cell proliferation and migration, promoted apoptosis, downregulated the levels of IL-1β (Interleukin-1β) and IL-6 (Interleukin-6), and inhibited α-SMA expression. Moreover, ZEB1 was highly expressed in HS tissues, and miR-431-5p negatively regulated ZEB1. Further investigation revealed that overexpression of ZEB1 could partially reverse the regulatory effects of miR-431-5p on cellular behavior.

conclusionsThe miR-431-5p/ZEB1 axis was involved in the regulation of HS.

Indexed as

Cicatrix, HypertrophicMicroRNAsZinc Finger E-box-Binding Homeobox 1ActinsAdultApoptosisCell MovementCell ProliferationDown-RegulationFemaleGene Expression RegulationHumansInterleukin-1betaInterleukin-6MaleMiddle AgedACTA2 protein, humanActinsIL6 protein, humanInterleukin-1betaInterleukin-6MicroRNAsMIRN431 microRNA, humanZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1HSFBshypertrophic scarmiR‐431‐5pZEB1

Identifiers

PMID41252548
PMCPMC12626391

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.