ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Phrenic long-term facilitation following acute intermittent hypercapnic-hypoxia in rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Sympathetic long-term facilitation following acute intermittent hypoxia is similar in the diurnal rest versus active phase in vagal-intact rats.Journal of neurophysiology · 2026Article
- Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats.Function (Oxford, England) · 2026Article
- Vagal suppression of diurnal variations in acute intermittent hypoxia-induced phrenic long-term facilitation.Journal of neurophysiology · 2026Article
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Abstract
Phrenic long-term facilitation (pLTF) is a form of respiratory motor plasticity, expressed as a lasting increase in phrenic nerve activity following acute intermittent hypoxia (AIH). Whereas AIH also elicits ventilatory LTF (vLTF) in unanesthetized rats, concurrent hypercapnia (elevated background or episodic hypercapnia) is required for vLTF in humans. One major difference between rodent and human studies is the diurnal phase (nocturnal rats vs. diurnal humans). Diurnal phase regulates pLTF magnitude and mechanism; 15, 1-min hypoxic episodes elicit more robust pLTF in the rest (∼130%) versus active phase (∼30%) in rats. Thus, we assessed differences in pLTF elicited by acute intermittent hypercapnic-hypoxia (AIHH) versus AIH in mid-rest versus mid-active phase rats. In anesthetized, paralyzed, vagotomized, and ventilated male Sprague-Dawley rats (
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