Evidence map›Paper›PMID 41252311›Full record

ArticleJournal of Parkinson's disease2026

Association of dopamine depletion and cholinergic basal forebrain atrophy with brain metabolism and cognition in Parkinson's disease.

Jung Hyun Lee, Mina Park, Sung Jun Ahn, Jae Hoon Lee, Young Hoon Ryu, Han Soo Yoo, Chul Hyoung Lyoo

Abstract read
In one paragraph

Article in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jung Hyun LeeDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.ORCID 0000-0001-5082-1075
Mina ParkDepartment of Radiology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
Sung Jun AhnDepartment of Radiology, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
Jae Hoon LeeDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.ORCID 0000-0002-9898-9886
Young Hoon RyuDepartment of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.
Han Soo YooDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Chul Hyoung LyooDepartment of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.ORCID 0000-0003-2231-672X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundCognitive dysfunction is one of the most debilitating non-motor symptoms of Parkinson's disease (PD). This study aimed to explore the interplay between altered neurotransmitter activities, including dopamine and acetylcholine, and brain metabolism in cognitive decline in PD.MethodsWe enrolled 172 PD patients (mean ± SD age 69.8 ± 8.6 years; 93 females) who underwent brain magnetic resonance imaging,

Indexed as

AcetylcholineBasal ForebrainCognitive DysfunctionDopamineParkinson DiseaseAgedAtrophyDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsPositron-Emission TomographyTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneAcetylcholineDopamineDopamine Plasma Membrane Transport ProteinsTropanesbasal forebraincognitiondopaminemetabolismparkinson's disease

Identifiers

PMID41252311
PMCPMC13347562

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.