Evidence map›Paper›PMID 41252294›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2026

Role of the two-pore domain potassium channel TREK-1 in hyperoxia- and mechanical stretch-induced alveolar epithelial injury.

Nairrita Majumder, Benjamin Lopez, Aren Kasparian, John Taylor, Kushal Chatterjee, Hannah Zhong, Maya Fabrizio, Marina Angelini, Tatiana Zyrianova, Riccardo Olcese and 1 more

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In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nairrita MajumderDepartment of Pediatrics, University of California, Los Angeles, California, United States.ORCID 0000-0002-7297-7019
Benjamin LopezDepartment of Pediatrics, University of California, Los Angeles, California, United States.
Aren KasparianDepartment of Pediatrics, University of California, Los Angeles, California, United States.
John TaylorDepartment of Pediatrics, University of California, Los Angeles, California, United States.
Kushal ChatterjeeDepartment of Pediatrics, University of California, Los Angeles, California, United States.
Hannah ZhongDepartment of Pediatrics, University of California, Los Angeles, California, United States.
Maya FabrizioDepartment of Pediatrics, University of California, Los Angeles, California, United States.
Marina AngeliniDepartment of Pediatrics, University of California, Los Angeles, California, United States.ORCID 0000-0003-4621-3784
Tatiana ZyrianovaDepartment of Pediatrics, University of California, Los Angeles, California, United States.
Riccardo OlceseDepartment of Anesthesiology & Perioperative Medicine, University of California, Los Angeles, California, United States.ORCID 0000-0003-4225-9814
Andreas SchwingshacklDepartment of Pediatrics, University of California, Los Angeles, California, United States.ORCID 0000-0002-5608-0199

Funding

Trek-1 Potassium Channels Protect from Hyperoxia-induced Acute Lung InjuryR01HL146821 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHWINGSHACKL, ANDREAS · 2020 to 2024
$2.8M
The Role of TREK-1 potassium channels in ARDSR01HL175464 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Andreas Schwingshackl · 2024 to 2026
$2.3M
The Molecular Transitions that Initiate EC Coupling in Skeletal MuscleR35GM131896 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OLCESE, RICCARDO · 2019 to 2023
$2.0M
American Heart Association (AHA) 20TPA35490010American Heart Association (AHA) 23CDA1052265American Heart Association (AHA) 25POST1366363American Lung Association (ALA) ALA CA- 1374253HHS | National Institutes of Health (NIH) NIH R01HL146821HHS | National Institutes of Health (NIH) R01HL175464HHS | National Institutes of Health (NIH) R35GM131896NHLBI NIH HHS R01 HL146821NHLBI NIH HHS R01 HL175464NIGMS NIH HHS R35 GM131896U.S. Department of Defense (DOD) W81XWH2210040
6 · The paper itself

Abstract

Hyperoxia (HO) and mechanical ventilation (MV) are the mainstay of treatment for patients with acute respiratory failure, but both interventions can also accelerate further lung injury, highlighting the need for better therapeutic approaches. We previously found that HO decreases epithelial TREK-1 expression and promotes epithelial inflammation, but the consequences of TREK-1 deficiency in a clinically relevant system of combined HO + ST (stretch) exposure remain unknown. We found that in both mouse lung tissue and primary human alveolar epithelial cells, HO + ST downregulates TREK-1 protein levels. The injurious consequences of TREK-1 downregulation are evidenced in alveolar epithelial cells following pharmacological and genetic TREK-1 inhibition and in lungs of TREK-1 KO mice by potentiation of HO + ST-induced cytosolic ROS production, caspase-8 and caspase-1 activation, IL-1β production, and MIP-1α, and CXCL-10/IP-10 secretion. In addition, HO + MV-exposed TREK-1 KO mice show increased histological lung injury scores, total cell, macrophage, and neutrophil counts in the bronchoalveolar lavage fluid (BALF). Mechanistically, HO + ST depolarized the epithelial electrical membrane potential (Em) and raised iCa

Indexed as

Alveolar Epithelial CellsHyperoxiaPotassium Channels, Tandem Pore DomainPulmonary AlveoliAnimalsHumansMaleMiceMice, Inbred C57BLMice, KnockoutReactive Oxygen SpeciesRespiration, Artificialpotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainReactive Oxygen SpecieshyperoxiaK2P2.1 KCNK2lung injurymechanical stretchTREK-1 two-pore domain potassium channel

Identifiers

PMID41252294
PMCPMC12716432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.