Evidence map›Paper›PMID 41252215›Full record

ArticleThe Journal of clinical investigation2026

Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model.

Karen Hoffmann, Ulrike Behrendt, Peter Pennitz, Holger Kirsten, Jessica Pohl, Elena Lopez-Rodriguez, Chantal Weissfuss, Jens Kollmeier, Mario Tönnies, Sebastian Brill and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karen HoffmannCharité - Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.
Ulrike BehrendtCharité - Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.
Peter PennitzCharité - Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.
Holger KirstenUniversität Leipzig, ScaDS.AI, Institute for Medical Informatics, Statistics, and Epidemiology, Leipzig, Germany.
Jessica PohlBundeswehr Hospital Berlin, Department of Internal Medicine, Berlin, Germany.
Elena Lopez-RodriguezCharité - Universitätsmedizin Berlin, Institute of Functional Anatomy, Berlin, Germany.
Chantal WeissfussCharité - Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.
Jens KollmeierRespiratory Diseases Clinic Heckeshorn, Helios Klinikum Emil von Behring GmbH, Berlin, Germany.
Mario TönniesRespiratory Diseases Clinic Heckeshorn, Helios Klinikum Emil von Behring GmbH, Berlin, Germany.
Sebastian BrillBundeswehr Hospital Ulm, Department for Thoracic-Surgery and Institute of Pathology and Molecular Pathology, Ulm, Germany.
Konrad SteinestelBundeswehr Hospital Ulm, Department for Thoracic-Surgery and Institute of Pathology and Molecular Pathology, Ulm, Germany.
Martin WitzenrathCharité - Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.
Werner WenzelBundeswehr Hospital Berlin, Department of Microbiology and Hospital Hygiene, Berlin, Germany.
Christian ZobelBundeswehr Hospital Berlin, Department of Internal Medicine, Berlin, Germany.
Geraldine NouaillesCharité - Universitätsmedizin Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using an advanced human lung-on-a-chip model, this study shows that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa.

Indexed as

Lab-On-A-Chip DevicesLungModels, BiologicalOrganoidsPneumoniaPneumonia, BacterialPseudomonas aeruginosaPseudomonas InfectionsStress, MechanicalHumansAdult stem cellsBacterial infectionsInfectious diseasePulmonology

Identifiers

PMID41252215
PMCPMC12807462

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.