Evidence map›Paper›PMID 41252189›Full record

ArticleeLife2025

Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish.

Laura Lopez-Blanch, Cristina Rodríguez-Marin, Federica Mantica, Luis P Iñiguez, Jon Permanyer, Elizabeth M Kita, Tahnee Mackensen, Mireia Codina-Tobias, Francisco Romero-Ferrero, Jordi Fernandez-Albert and 4 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Laura Lopez-BlanchCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Cristina Rodríguez-Marin *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID https://orcid.org/0000-0001-6772-4853
Federica Mantica *Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Luis P IñiguezCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID https://orcid.org/0000-0002-1470-9024
Jon PermanyerCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Elizabeth M KitaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Tahnee MackensenCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID https://orcid.org/0000-0002-6537-7592
Mireia Codina-TobiasCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID https://orcid.org/0009-0003-6005-270X
Francisco Romero-FerreroCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Jordi Fernandez-AlbertCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Myriam CuadradoInstituto de Biología Molecular y Celular del Cáncer, CSIC and Universidad de Salamanca, Salamanca, Spain.ORCID https://orcid.org/0000-0001-9410-1205
Xosé R BusteloInstituto de Biología Molecular y Celular del Cáncer, CSIC and Universidad de Salamanca, Salamanca, Spain.ORCID https://orcid.org/0000-0001-9398-6072
Gonzalo de PolaviejaChampalimaud Research, Champalimaud Foundation, Lisbon, Portugal.ORCID https://orcid.org/0000-0001-5359-3426
Manuel IrimiaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID https://orcid.org/0000-0002-2179-2567

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2021 SGR-Cat 01220Agencia Estatal de Investigación PID2020-115040GB-I00/AEI/10.13039/501100011033Agencia Estatal de Investigación PID2021-122666OB-I00Agencia Estatal de Investigación PID2024-156980OB-I00Asociación Española Contra el Cáncer EPAEC222641CICSConsejeria de Educación, Junta de Castilla y León CSI018P23Consejería de Educación, Junta de Castilla y León CLU-2023-2-01European Commission 10.3030/101002275European Commission 10.3030/637591Fundação para a Ciência e Tecnologia PTDC/BIA-COM/5770/2020Spanish Ministry of Science and Innovation CEX2020-001049-SSpanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033
6 · The paper itself

Abstract

Microexons exhibit striking evolutionary conservation and are subject to precise, switch-like regulation in neurons, orchestrated by the splicing factors

Indexed as

ExonsNeuronsRNA Splicing FactorsZebrafishZebrafish ProteinsAnimalsLocomotionNeurogenesisPhenotypeSocial BehaviorRNA Splicing FactorsZebrafish Proteinscompensationgeneticsgenomicsmaster regulatorsmicroexonszebrafish

Identifiers

PMID41252189
PMCPMC12626424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.