Evidence map›Paper›PMID 41252154›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5.

Pia E Ferle, Niklas Krause, Judith Koliwer, Jörn Michael Völker, Fabia Becker, Alexander Hillebrand, Leonie F Schröder, Stefanie Jäger, Seby Edassery, Dali Liu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The lactate sensor NDRG3 decelerates ER-to-Golgi transport through interaction with the long isoform of syntaxin-5.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pia E Ferle *Faculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.ORCID 0009-0005-2598-0898
Niklas Krause *Faculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.
Judith Koliwer *Faculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.
Jörn Michael VölkerFaculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.ORCID 0000-0002-2407-2557
Fabia BeckerFaculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.
Alexander HillebrandFaculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.ORCID 0000-0003-0515-655X
Leonie F SchröderFaculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.ORCID 0000-0003-1064-6350
Stefanie JägerMedical School Hamburg, University of Applied Sciences and Medical University, Hamburg 20457, Germany.
Seby EdasseryDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0003-1129-748X
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University of Chicago, Chicago, IL 60660.ORCID 0000-0002-7587-703X
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158.ORCID 0000-0003-4902-337X
Jeffrey N SavasDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0002-8173-5580
Gabriele Fischer von MollardFaculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.ORCID 0000-0003-3236-1401
Michael SchwakeFaculty of Chemistry, Biochemistry III (BCIII), University of Bielefeld, Bielefeld 33615, Germany.ORCID 0000-0002-4173-2166

Funding

Orbitrap Eclipse Mass Spectrometer for Northwestern University Neuroproteomic Collaboration HubS10OD032464 · OD · NORTHWESTERN UNIVERSITY · PI SAVAS, JEFFREY NICHOLAS · 2023 to 2023
$1.3M
Deutsche Forschungsgemeinschaft (DFG) FI 583/7-1 -2Deutsche Forschungsgemeinschaft (DFG) INST215/423-1 FUGGDeutsche Forschungsgemeinschaft (DFG) SCHW 866/10-1Deutsche Forschungsgemeinschaft (DFG) SCHW 866/5-1 and -2NIH HHS S10 OD032464
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Endoplasmic ReticulumGolgi ApparatusLactic AcidNerve Tissue ProteinsQa-SNARE ProteinsAnimalsHEK293 CellsHeLa CellsHumansProtein BindingProtein IsoformsProtein TransportLactic AcidNerve Tissue ProteinsProtein IsoformsQa-SNARE Proteinscongenital muscular dystrophyhypoxialactateSNAREsyntaxin-5

Identifiers

PMID41252154
PMCPMC12663949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.