ArticleMolecular imaging and biology2025
In-Ovo Imaging with Ostrich Eggs: Eggshell Attenuation in CT and Limitations of Organ Dosimetry.
Article in Molecular imaging and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Ostrich eggs have recently attracted interest as an alternative model in preclinical nuclear medicine imaging. The ability to be used in clinical PET/CT (positron emission tomography/computed tomography) systems and their ethical profile are advantageous over conventional rodent models and other avian systems. Nevertheless, concerns regarding radiation exposure during repeated CT (computed tomography) imaging of developing embryos remain inadequately addressed. This study aimed to characterize the attenuation impact of eggshells in ostrich eggs and to evaluate the potential for organ-specific dose assessment. A representative ostrich egg was selected from a cohort of 168 eggs and used to construct a dimensionally matched 3D-printed phantom. Organ weights of 83 embryos were documented on development day (DD) 37 to provide a basis for future organ-level dosimetric modeling. Thermoluminescence dosimeters (TLDs) were positioned along the z-axis within both the egg and phantom, and CT dose distributions were measured using a clinical PET/CT system. The mean absorbed dose in the real egg was 16.3 ± 2.0% lower than in the phantom, attributable to radiation attenuation by the 1.89 ± 0.12 mm thick eggshell. CTDI (computed tomography dose index) values remained stable across developmental stages (DD 0-37). Our findings confirm that the ostrich eggshell exerts a significant shielding effect during CT imaging. While ostrich eggs are suitable for serial in-ovo imaging, embryo positioning remains a major limitation for precise dosimetry. Organ weight data enable potential use of AI (artificial intelligence)-based modeling to improve spatial dosimetry accuracy. This study provides essential groundwork for dose optimization and radioprotection in preclinical imaging protocols using ostrich eggs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.