Evidence map›Paper›PMID 41252041›Full record

Observational studyBreast cancer (Tokyo, Japan)2026

Breast reconstruction-related complications from postmastectomy radiation therapy in stage II-III breast cancer: sub-analysis of a multi-institutional observational study (Reborn-03).

Shinsuke Sasada, Wakako Tsuji, Noriyuki Watanabe, Ayaka Shimo, Natsue Uehiro, Takahiro Tsukioki, Naomi Nagura, Shoichi Tomita, Hiroko Nogi, Kei Yamaguchi and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Breast cancer (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shinsuke SasadaDepartment of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan. shsasada@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0003-1623-869X
Wakako TsujiDepartment of Breast Surgery, Shiga General Hospital, Moriyama, Shiga, Japan.
Noriyuki WatanabeDepartment of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan.
Ayaka ShimoDepartment of Breast and Endocrine Surgery, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Natsue UehiroDepartment of Breast Surgical Oncology, Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Takahiro TsukiokiDepartment of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Naomi NaguraDepartment of Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan.
Shoichi TomitaDepartment of Plastic and Reconstructive Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Hiroko NogiDepartment of Breast and Endocrine Surgery, Jikei University School of Medicine, Tokyo, Japan.
Kei YamaguchiDepartment of Breast Surgery, Saitama Medical Center, Saitama, Japan.
Kazuhiko YamagamiDepartment of Breast Surgery, Shinko Hospital, Kobe, Hyogo, Japan.
Akiko OgiyaDepartment of Breast Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Hiromi SuetsuguDepartment of Breast Surgery, Kyoto City Hospital, Kyoto, Japan.
Yuki NakamuraDepartment of Breast Surgery, Kyoto University Hospital, Kyoto, Japan.
Chikako YamauchiDepartment of Breast Surgery, Shiga General Hospital, Moriyama, Shiga, Japan.
Hirohito SekiDepartment of Breast Surgery, Kyorin University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough postmastectomy radiation therapy (PMRT) is a standard treatment for high-risk breast cancer, it adds the risk of complications after breast reconstruction (BR).

methodsThis multi-institutional cohort study included patients with stage II-III breast cancer-defined as tumor size ≥ 5 cm, lymph node involvement, and/or skin/chest wall invasion-who underwent immediate or delayed BR after mastectomy between January 2008 and December 2018. We retrospectively investigated the relationship between PMRT and BR-related complications after adjusting for patient characteristics and BR method.

resultsAmong 1138 patients (1101 immediate and 37 delayed BR), 427 (37.5%) underwent PMRT. The cohort included 238 (20.9%) patients with tumors ≥ 5 cm, 725 (63.7%) with 1-3 lymph node metastases, and 257 (22.6%) with ≥ 4. BR methods included 750 prosthetic, 385 autologous, and 3 fat graft procedures. The overall complication rates were 25.2% and 31.5% in the non-PMRT and PMRT groups, respectively (p = 0.028). In prosthetic BR, capsule contracture (p < 0.001) and infection (p = 0.014) were more frequent in the PMRT than the non-PMRT group, whereas no significant difference was observed in complication rates between two groups in autologous BR. Multivariate analysis identified PMRT as an independent risk factor for BR-related complications (odds ratio, 1.47; p = 0.032). The reoperation rate was similar in two groups.

conclusionsPMRT was associated with an increased incidence of BR-related complications in prosthetic BR, but not with reoperation, irrespective of the reconstruction method.

Indexed as

Breast NeoplasmsMammaplastyPostoperative ComplicationsAdultAgedFemaleHumansMastectomyMiddle AgedNeoplasm StagingRadiotherapy, AdjuvantRetrospective StudiesBreast cancerBreast reconstructionMastectomyPostmastectomy radiation therapyPostoperative complication

Identifiers

PMID41252041
PMCPMC12789235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.