Evidence map›Paper›PMID 41251969›Full record

ReviewPhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

Pro-tumor effects of nitric oxide from stress-upregulated inducible nitric oxide synthase in anti-tumor photodynamic therapy.

Albert W Girotti, Mladen Korbelik

Abstract readReview
PubMed Publisher
In one paragraph

Review in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Albert W GirottiDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. agirotti@mcw.edu.
Mladen KorbelikDepartment of Integrative Oncology, BC Cancer, Vancouver, BC, VSC 113, Canada.

Funding

BSC FP12605Cancer Center, Medical College of Wisconsin Rock River Grant FP14869U.S. Public Health Service CA70823
6 · The paper itself

Abstract

Non-invasive photodynamic therapy (PDT) is an increasingly applied modality for solid tumors. Many malignant cells that can withstand PDT upregulate nitric oxide, which not only acts cytoprotectively, but stimulates growth and migration of surviving cells. These anti-PDT responses are still not well-recognized by PDT researchers and practitioners. We provide here a background on these negative effects and offer perspectives on how they can be suppressed for a therapeutic benefit, e.g. by inhibiting transcription of inducible nitric oxide synthase.

Indexed as

NeoplasmsNitric OxideNitric Oxide Synthase Type IIPhotochemotherapyAnimalsHumansPhotosensitizing AgentsUp-RegulationNitric OxideNitric Oxide Synthase Type IIPhotosensitizing AgentsBET inhibitorsBET proteinsInducible nitric oxide synthase (iNOS)iNOSNO upregulationiNOS upregulation signalingNitric oxide (NO)NO-mediated tumor cell aggressivenessPhotodynamic therapyPhotooxidative stressPro-tumor NOS-nitrosation

Identifiers

PMID41251969

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.