ArticleAnnals of surgical oncology2026
Sentinel Node Biopsy Alone Versus Sentinel Node Biopsy Plus Axillary Dissection in cT2 cN0/1 Breast Cancer After Neoadjuvant Chemotherapy: 15-Year Results of a Prospective Interventional Study.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pressurised intraperitoneal aerosol chemotherapy (PIPAC) for peritoneal metastases: a scoping review of clinical evidence across emerging indications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- ASO Author Reflections: No Further Axillary Treatment is Safe if the Sentinel Nodes are Negative After Neoadjuvant Chemotherapy in cT2 cN1 Breast Cancer.Annals of surgical oncology · 2026Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundRecent guidelines recommend sentinel lymph node biopsy (SNB) of cN1 breast cancer when the axilla is clinically clear after neoadjuvant chemotherapy (NAC). It remains controversial whether further axillary treatment is required if the axillary sentinel nodes (SNs) are pN0.
methodsThis prospective non-randomized study analyzed 486 consecutive patients with cT2 cN0/1 breast cancer recruited from 2007 through 2021. Axillary status was assessed by palpation and ultrasound only. After NAC, patients who were cN0 underwent SNB. Those with negative SNs usually received no further axillary treatment, and those with involved SNs usually received AD. The primary end points were overall and disease-free survival for the SNB-only versus the SNB+AD patients, as estimated by the Kaplan-Meier method and log-rank test, with application of a propensity score because treatment assignment was not randomized.
resultsAfter a median follow-up of 102 months (interquartile range [IQR], 59-162 months) for the SNB-only patients and 200 months (IQR, 168-213 months) for the SNB+AD patients, overall and disease-free survival did not differ between the pN0 SNB-only and the pN0 SNB+AD patients. Furthermore, no SNB-only patient experienced axillary recurrence.
conclusionsFor cT2 CN0/1 breast cancer patients who are cN0 after NAC, SNB can be offered, with no further axillary treatment if the SNs are negative, irrespective of axillary status beforehand, with no adverse effect on long-term outcomes.
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