Evidence map›Paper›PMID 41251899›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2025

Longitudinal Vibrations in the Organ of Corti are Limited to Its Core.

Sebastiaan W F Meenderink, Marcel van der Heijden, Wei Dong

Abstract read
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sebastiaan W F MeenderinkVA Loma Linda Healthcare System, Loma Linda, CA, 92374, USA.ORCID http://orcid.org/0000-0001-5487-2232
Marcel van der HeijdenDepartment of Neuroscience, Erasmus MC, 3000 CA, Rotterdam, the Netherlands.
Wei DongVA Loma Linda Healthcare System, Loma Linda, CA, 92374, USA. Wei.Dong@va.gov.ORCID http://orcid.org/0000-0002-3771-1901

Funding

RRD VA I01 RX003491
6 · The paper itself

Abstract

purposeThe goal of this research was to determine where in the organ of Corti (ooC) sound-induced, longitudinal vibrations occur, and how they depend on the health of the cochlea.

methodsSound-evoked vibrations of the ooC in the cochlea's middle turn of adult anesthetized gerbils were measured using optical coherence tomography (OCT). Vibratory responses, evoked with acoustic tone complexes, were recorded at multiple, closely spaced (20 μm), tonotopic locations which changed the "viewing angle" of the vertical OCT beam re. the longitudinal motion. After spatial alignment of the responses, within-ooC regions exhibiting sound-induced longitudinal motion were identified from a conspicuous 180° phase flip.

resultsLongitudinal motion was restricted to the outer hair cells (OHC), Deiters' cells and the tunnel of Corti (i.e., the ooC's "core"). They were frequency and level-independent but did depend on the ear's metabolic state; after death, they disappeared.

conclusionThere can be little doubt about the presence of longitudinal motions within the cochlea. Their disappearance postmortem and spatially restricted occurrence suggest these longitudinal vibrations arise from active processes within the OHC. Whether this involves cycle-by-cycle feedback or some other, as-of-yet undetermined, mechanism remains to be resolved.

Indexed as

Organ of CortiVibrationAcoustic StimulationAnimalsGerbillinaeMaleTomography, Optical CoherenceCochlear mechanicsGerbilLongitudinal motionOptical coherence tomographyVibrometry

Identifiers

PMID41251899
PMCPMC12698914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.