SynthesisObesity surgery2025
Comparative Risk of Gallstone Formation After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass: A Systematic Review and Meta-Analysis.
Synthesis in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the risk of gallstone formation after sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB).
methodsWe searched PubMed, Scopus, Web of Science, and Embase following PRISMA 2020. Eligible observational studies reported incident cholelithiasis after SG or RYGB. Risk of bias was assessed with the Newcastle-Ottawa Scale (NOS). Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using random-effects (DerSimonian-Laird). Prespecified subgroup analyses considered follow-up duration (< 2 vs. ≥ 2 years).
resultsTen studies (n = 195,665) met inclusion criteria. Overall, SG was associated with a lower risk of gallstone formation than RYGB (OR 0.68, 95% CI 0.53-0.88; p = 0.003; I²=75%). The protective association was evident in studies with < 2 years of follow-up (OR 0.59, 95% CI 0.42-0.82; I²=46%) but not in ≥ 2-year follow-up (OR 0.84, 95% CI 0.55-1.28; I²=70%). In influence analysis excluding the largest database study, the summary effect became statistically non-significant with extreme heterogeneity (OR 0.31, 95% CI 0.03-2.72; I²=99%). Methodological quality was moderate to high (NOS 6-8/9).
conclusionsSG is associated with a lower short-term risk of gallstone formation compared with RYGB, although results are heterogeneous and sensitive to study weight. Standardized outcome definitions, longer follow-up, and stratification by UDCA use are needed to refine comparative risk estimates.
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Registered trials
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