Evidence map›Paper›PMID 41251880›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026

Safety, survival outcomes, and prognostic factors in conversion surgery for advanced gastric cancer: a sub-analysis of Japanese patients in the CONVO-GC-1 study.

Itaru Yasufuku, Takahiro Kinoshita, Etsuro Bando, Yukinori Kurokawa, Muneharu Fujisaki, Hitoshi Ojima, Takaaki Arigami, Seito Fujibayashi, Masahiro Watanabe, Kenichiro Furukawa and 2 more

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Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Prognosis-predicting factor of gastrectomy after systemic cancer therapy for cStage IVB gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Itaru YasufukuDepartment of Clinical Anatomy Development Studies, Gifu University Graduate School of Medicine, Gifu, Japan.
Takahiro KinoshitaDepartment of Gastric Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Etsuro BandoDivision of Gastric Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.
Yukinori KurokawaDepartment of Gastroenterological Surgery, Osaka University, Osaka, Japan.
Muneharu FujisakiDepartment of surgery, The Jikei University School of Medicine, Tokyo, Japan.
Hitoshi OjimaDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, Gunma, Japan.
Takaaki ArigamiDepartment of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Seito FujibayashiDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Masahiro WatanabeDepartment of Gastric Surgery, National Cancer Center Hospital East, Kashiwa, Japan.
Kenichiro FurukawaDivision of Gastric Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.
Nobuhisa MatsuhashiDepartment of Gastroenterological and Pediatric Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Masanori TerashimaDivision of Gastric Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan. m.terashima@scchr.jp.ORCID 0000-0002-2967-8267

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognostic factors for conversion surgery in patients with metastatic gastric cancer remain unclear. This study aimed to identify the prognostic factors associated with conversion surgery, and evaluate the safety and survival outcomes of conversion surgery using data from Japanese patients enrolled in the CONVO-GC-1 study.

methodsClinical background, chemotherapy before and after surgery, surgical outcomes, postoperative complications, and survival were analyzed. Prognostic factors were assessed using univariate and multivariate regression analyses.

resultsA total of 773 Japanese patients were included. Categories 1, 2, 3, and 4 included 345, 156, 225, and 47 patients, respectively. R0 resection was achieved in 571 (73.9%) patients. Incidence rate of Clavien-Dindo grade ≥ III complications was 12.0%. Surgery-related mortality rate was 0.1%. Median overall survival (OS) among patients with R0 resection was 47.8 months. The OS of patients with R0 resection by category was 47.6, 116.6, 40.1, and 54.4 months for categories 1, 2, 3, and 4, respectively. In the multivariate analysis, male sex (hazard ratio [HR], 1.70; 95% confidence interval [CI], 1.30-2.22), undifferentiated histological type (HR, 1.35; 95% CI 1.04-1.75), Eastern Cooperative Oncology Group Performance Status ≥ 1 (HR, 1.57; 95% CI 1.18-2.08), ypT4 (HR,1.79; 95% CI 1.38-2.33), ypN + (HR, 1.92; 95% CI 1.42-2.58), and preoperative chemotherapy duration < 6 months (HR, 1.43; 95% CI 1.10-1.87) were poor prognostic factors.

conclusionConversion surgery was safely performed, yielding favorable survival outcomes in patients with R0 resection. Therefore, careful patient selection is warranted, particularly in those with poor prognostic indicators.

Indexed as

GastrectomyStomach NeoplasmsAdultAgedAged, 80 and overEast Asian PeopleFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedPostoperative ComplicationsPrognosisSurvival RateChemotherapyGastrectomyNeoplasm metastasisPrognosisStomach neoplasms

Identifiers

PMID41251880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.