Evidence map›Paper›PMID 41251859›Full record

ReviewDiscover oncology2025

Applications of bioluminescence-mediated photodynamic therapy (BL-PDT) for the treatment of deep-seated tumours.

Mpho Mohlongo, Blassan P George, Heidi Abrahamse

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mpho MohlongoLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.
Blassan P GeorgeLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa. blassang@uj.ac.za.
Heidi AbrahamseLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa. habrahamse@uj.ac.za.

Funding

African Laser Centre, Council for Scientific and Industrial Research HLHA26X Task ALC-R001National Research Foundation 137788National Research Foundation 98337South African Medical Research Council EIP007/2021
6 · The paper itself

Abstract

Bioluminescence, the light generated through biochemical reactions involving luciferases in living organisms, has been the focus of extensive research due to its diverse applications. It is especially noteworthy as an internal light source for theranostic applications because of its safety and efficiency, which helps to overcome the challenges associated with the poor penetration of traditional external light sources. Recent progress in protein engineering and delivery systems has broadened the scope of bioluminescence in numerous applications, including photodynamic therapy. This review outlines the essential principles of bioluminescence and examines its recent applications in photodynamic therapy for the treatment of cancers. Additionally, it offers insights into future research avenues based on the current studies in bioluminescent systems to further enhance their potential.

Indexed as

BioluminescenceBioluminescence-activated photodynamic therapyBioluminescence resonance energy transferDeep-tissue tumoursPhotodynamic therapy

Identifiers

PMID41251859
PMCPMC12627325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.