Evidence map›Paper›PMID 41251800›Full record

ArticleJournal of gastroenterology2026

Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan.

Akiyoshi Tsuboi, Shiro Oka, Takeshi Yamada, Keigo Mitsui, Hironori Yamamoto, Keiichi Takahashi, Akio Shiomi, Kinichi Hotta, Yoji Takeuchi, Toshio Kuwai and 46 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Akiyoshi TsuboiDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. oka4683@hiroshima-u.ac.jp.ORCID 0000-0002-1773-8293
Takeshi YamadaDepartment of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.
Keigo MitsuiDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Hironori YamamotoDepartment of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Keiichi TakahashiDepartment of Colorectal Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Akio ShiomiDivision of Colon and Rectal Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Kinichi HottaDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Yoji TakeuchiDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Toshio KuwaiDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan.
Fumio IshidaDigestive Disease Center, Showa Medical University Northern Yokohama Hospital, Kanagawa, Japan.
Shin-Ei KudoDigestive Disease Center, Showa Medical University Northern Yokohama Hospital, Kanagawa, Japan.
Shoichi SaitoDepartment of Lower Gastrointestinal Medicine, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan.
Masashi UenoDepartment of Gastroenterological Surgery, Toranomon Hospital, Tokyo, Japan.
Eiji SunamiDepartment of Surgery, Kyorin University School of Medicine, Tokyo, Japan.
Tomoki YamanoDivision of Lower Gastrointestinal Surgery, Department of Surgery, Hyogo Medical University, Hyogo, Japan.
Michio ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Kazuo OhtsukaDepartment of Gastroenterology and Hepatology, Institute of Science Tokyo, Tokyo, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Takayuki MatsumotoDivision of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Iwate, Japan.
Tamotsu SugaiDepartment of Diagnostic Pathology, Iwate Medical University, Iwate, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Koichi KuraharaDivision of Gastroenterology, Matsuyama Red Cross Hospital, Ehime, Japan.
Shigeki YamaguchiDepartment of Gastroenterological Surgery, Saitama Medical University International Medical Center, Saitama, Japan.
Tomohiro KatoDepartment of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan.
Masazumi OkajimaDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Hiroshi KashidaDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
Fumihiko FujitaDepartment of Surgery, Kurume University School of Medicine, Fukuoka, Japan.
Hiroaki IkematsuDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.
Masaaki ItoDepartment of Colorectal Surgery, National Cancer Center Hospital East, Chiba, Japan.
Motohiro EsakiDivision of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
Masaya KawaiDepartment of Coloproctological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Takashi YaoDepartment of Human Pathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Madoka HamadaDepartment of Gastrointestinal Surgery, Kansai Medical University Hospital, Osaka, Japan.
Takahiro HorimatsuDepartment of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.
Keiji KodaDepartment of Surgery, Teikyo University Chiba Medical Center, Chiba, Japan.
Yasumori FukaiDepartment of Gastroenterology, Maebashi Red Cross Hospital, Gunma, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Yusuke SaitohDepartment of Gastroenterology, Asahikawa City Hospital, Hokkaido, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Hiroyuki TakamaruEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Kazutaka YamadaDepartment of Surgery, Coloproctology Center Takano Hospital, Kumamoto, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Tetsuji TakayamaDepartment of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Kazutomo TogashiDepartment of Coloproctology, Aizu Medical Center, Fukushima Medical University, Fukushima, Japan.
Eiji ShintoDepartment of Surgery, National Defense Medical College, Saitama, Japan.
Takehiro TorisuDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akira ToyoshimaDepartment of Colorectal Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
Naoki OhmiyaDepartment of Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.
Takeshi KatoDepartment of Surgery, NHO Osaka National Hospital, Osaka, Japan.
Eigo OtsujiDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Shinji NagataDepartment of Gastroenterology, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Yojiro HashiguchiDepartment of Surgery, Japanese Red Cross Omori Hospital, Tokyo, Japan.
Kenichi SugiharaInstitute of Science Tokyo, Tokyo, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Shinji TanakaDepartment of Gastroenterology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOwing to the rarity of metastatic tumors in the small bowel, their clinicopathological features, and prognostic factors remain poorly understood. This study aimed to clarify the clinicopathological features and factors associated with the prognosis of patients with small bowel metastasis from other organs in Japan.

methodsWe retrospectively examined 253 patients who were histopathologically diagnosed with small bowel metastases between January 2008 and December 2017 at multiple institutions in Japan. We identified the clinicopathological features of the condition and determined the factors associated with the prognosis of these patients.

resultsObstructive symptoms were the most frequent clinical presentations (39% abdominal pain and 18% vomiting), while gastrointestinal bleeding was observed in 27% of patients. The diagnostic modalities included enteroscopy (33%), balloon-assisted enteroscopy (30%), and capsule endoscopy (13%). The most common primary tumor was lung cancer (38%), followed by colorectal cancer (18%), gastric cancer (9%), and malignant melanoma (6%). Surgical intervention, including tumor resection or bypass surgery, was performed in 79% of patients. The cumulative survival rates of patients at 12, 24, and 60 months were 49%, 36%, and 22%, respectively. Multivariate analysis identified surgery as a significant factor for improving overall survival (HR = 0.56, 95% CI 0.35-0.89, p = 0.01).

conclusionsThe lung cancer is the most frequent primary tumor of metastatic tumors in the small bowel. Surgical intervention was associated with improved survival outcomes.

Indexed as

Intestinal NeoplasmsIntestine, SmallAbdominal PainAdultAgedAged, 80 and overColorectal NeoplasmsDatabases, FactualFemaleGastrointestinal HemorrhageHumansJapanLung NeoplasmsMaleMiddle AgedPrognosisEnteroscopyMetastatic tumorPrimary tumorSmall bowel

Identifiers

PMID41251800
PMCPMC12987839

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