Evidence map›Paper›PMID 41251764›Full record

SynthesisJournal of neural transmission (Vienna, Austria : 1996)2026

Resting-state EEG changes associated with cognitive decline in Parkinson's disease: a systematic review.

Milena Spoa, Sara Monti, Jovana Bjekić, Andrea Guerra, Eleonora Fiorenzato, Simone Cauzzo, Alessandra Bertoldo, Angelo Antonini

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milena Spoa *Padova Neuroscience Center, University of Padova, Padua, Italy.ORCID http://orcid.org/0009-0007-0178-9284
Sara Monti *Padova Neuroscience Center, University of Padova, Padua, Italy.ORCID http://orcid.org/0009-0000-5816-6562
Jovana BjekićHuman Neuroscience Group, Centre for Neuroscience and Neuromodulation, Institute for Medical Research, University of Belgrade, Belgrade, Serbia.ORCID http://orcid.org/0000-0001-7413-0324
Andrea GuerraNeurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padova, Padua, Italy.ORCID http://orcid.org/0000-0001-6601-4964
Eleonora FiorenzatoNeurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padova, Padua, Italy.ORCID http://orcid.org/0000-0001-7947-5903
Simone CauzzoNeurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padova, Padua, Italy.ORCID http://orcid.org/0000-0002-9237-5269
Alessandra BertoldoPadova Neuroscience Center, University of Padova, Padua, Italy.ORCID http://orcid.org/0000-0002-6262-6354
Angelo AntoniniNeurodegenerative Disease Unit, Centre for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, Padua Neuroscience Center (PNC), University of Padova, Padua, Italy. angelo.antonini@unipd.it.ORCID http://orcid.org/0000-0003-1040-2807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive decline is a common and disabling feature of Parkinson's disease (PD), frequently progressing from mild cognitive impairment to Parkinson's disease dementia. Due to substantial heterogeneity in PD phenotypes, current research is increasingly focused on identifying robust biomarkers to predict which individuals are at higher risk of cognitive deterioration relative to those likely to exhibit cognitive stability. Electroencephalography (EEG), a non-invasive and cost-efficient method for measuring neural activity, has shown potential in detecting early electrophysiological alterations associated with cognitive decline in PD. This review aims to summarise recent findings on the utility of resting-state quantitative EEG measures as candidate biomarkers for cognitive trajectory in PD. Relevant studies from over the last 10 years were retrieved through PubMed and Scopus, resulting in the inclusion and evaluation of 67 articles. Distinct EEG features, identified using various analytic approaches, were found to discriminate PD patients across different cognitive stages, as well as from those cognitively unimpaired and healthy controls. We suggest that EEG surrogate markers may be a valuable tool in conjunction with clinical and genetic variables to help early detection and monitoring, as well as development of personalised interventions for cognitive impairment in PD.

Indexed as

Cognitive DysfunctionElectroencephalographyParkinson DiseaseBiomarkersHumansBiomarkersCognitive declineElectroencephalographyParkinson’s diseaseqEEGResting state

Identifiers

PMID41251764
PMCPMC13149711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.