Evidence map›Paper›PMID 41251733›Full record

ArticleAbdominal radiology (New York)2026

Comparative efficacy and workflow efficiency of integrated PET/MRI versus sequential PET/CT and MRI in gynecologic cancer staging: a prospective single-center study.

Mayur Virarkar, Sanaz Javadi, Aatiqah Aziz, Jia Sun, Revathy Iyer, Rohini Chahal, Sherif B Elsherif, Nancy Swatson, Priya Bhosale

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mayur VirarkarUniversity of Florida, Jacksonville, USA. mayur.virarkar@jax.ufl.edu.
Sanaz JavadiThe University of Texas MD Anderson Cancer Center, Houston, USA.
Aatiqah AzizThe University of Texas MD Anderson Cancer Center, Houston, USA.
Jia SunThe University of Texas MD Anderson Cancer Center, Houston, USA.
Revathy IyerThe University of Texas MD Anderson Cancer Center, Houston, USA.
Rohini ChahalThe University of Texas MD Anderson Cancer Center, Houston, USA.
Sherif B ElsherifNYU Langone Health, New York, NY, 10016, USA.
Nancy SwatsonThe University of Texas MD Anderson Cancer Center, Houston, USA.
Priya BhosaleThe University of Texas MD Anderson Cancer Center, Houston, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo compare the diagnostic performance of PET/MRI versus PET/CT for lymph node and metastatic disease detection in patients with gynecologic cancers, and to assess whether PET/MRI offers improved staging accuracy and operational efficiency. MATERIALS: 49 patients with known gynecologic malignancies underwent both PET/CT and PET/MRI as part of a prospective study. Imaging protocols followed standard guidelines for each modality, with PET/CT and PET/MRI performed consecutively. Images were independently evaluated by experienced radiologists who assessed primary tumor, nodal, and metastatic disease. Subgroup analysis was performed for cervical cancer patients. Each patient's time in the imaging department for each scan was recorded, and statistical analysis included calculation of sensitivity, specificity, McNemar testing, and Cohen's Kappa for inter-rater agreement.

resultsThis study prospectively confirms prior findings of PET/MRI's superior nodal detection in gynecologic cancers while providing novel evidence regarding operational efficiency and workflow optimization. PET/MRI demonstrated superior detection of nodal metastases compared to PET/CT, identifying additional adenopathy in 5 patients (p = 0.031) and leading to staging changes in 18 patients within the cohort. In the cervical cancer subset, PET/MRI resulted in more upstaging and downstaging events, though subgroup statistical significance was not reached. PET/MRI also identified more primary tumors missed by PET/CT. The average total imaging time was significantly reduced with PET/MRI (180.3 min) compared to the combined PET/CT and MRI workflow (291.2 min), reflecting a 38.1% reduction in time burden. Qualitative assessment rated PET/MRI superior to PET/CT in 67.3% of cases.

conclusionWhile diagnostic superiority confirms current literature, this study provides the first prospective quantitative assessment of workflow efficiency in gynecologic oncology imaging. PET/MRI outperforms PET/CT in the detection of nodal disease and in overall diagnostic evaluation for patients with gynecologic cancers. In addition to superior staging accuracy, PET/MRI reduces patient time burden, supporting its use as a preferred, patient-centric imaging modality. Wider clinical adoption and further research are warranted to validate these findings in larger, multi-institutional cohorts.

Indexed as

Genital Neoplasms, FemaleMagnetic Resonance ImagingMultimodal ImagingPositron-Emission TomographyPositron Emission Tomography Computed TomographyAdultAgedFemaleHumansLymphatic MetastasisMiddle AgedNeoplasm StagingProspective StudiesSensitivity and SpecificityWorkflowDetectionGynecologicLymph nodePET/CTPET/MRI

Identifiers

PMID41251733

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.