Evidence map›Paper›PMID 41251707›Full record

Trial reportJournal of anesthesia2026

Incidence of hyponatremia with different postoperative intravenous maintenance fluids: a single-center, prospective, randomized trial.

Naotaka Shirakawa, Masahiro Ushio, Nana Furushima, Daichi Fujimoto, Shohei Makino, Yuki Nomura, Norihiko Obata, Satoshi Mizobuchi

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Naotaka ShirakawaDepartment of Anesthesiology, Kobe University Hospital, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
Masahiro UshioDepartment of Anesthesiology, Kobe University Hospital, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0017, Japan. masahirou0322@gmail.com.
Nana FurushimaDivision of Pediatric Critical Care Medicine, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima-Minamimachi, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0047, Japan.
Daichi FujimotoDepartment of Anesthesiology, Kobe University Hospital, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
Shohei MakinoDepartment of Anesthesiology, Kobe University Hospital, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
Yuki NomuraDepartment of Anesthesiology, Kobe University Hospital, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
Norihiko ObataDepartment of Anesthesiology, Kobe University Hospital, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe City, Hyogo Prefecture, 650-0017, Japan.
Satoshi MizobuchiDepartment of Anesthesiology, Sanda City Hospital, 3-3-1 Keyakidai, Sanda City, Hyogo Prefecture, 669-1321, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients undergoing surgery are prone to postoperative hyponatremia, which can lead to delirium. However, the optimal sodium concentration for postoperative maintenance fluids in adult patients is still unclear. Therefore, this study examined the incidence of hyponatremia and delirium in postoperative patients.

methodsThis was a single-center, non-blinded, randomized trial. The inclusion criteria for this study were age 20 years or older and elective head and neck cancer or esophageal cancer surgery between April 2018 and June 2023. Patients were randomly assigned to one of three groups based on the sodium concentration in the intravenous fluids administered after surgery: the 140 mmol/L sodium (Na

resultsA total of 105 patients had complete data at the end of the study: Na

conclusionThe use of postoperative fluids with a sodium concentration of 140 mmol/L significantly reduced the incidence of hyponatremia. There was no significant difference in the incidence of postoperative delirium.

Indexed as

Fluid TherapyHyponatremiaPostoperative CarePostoperative ComplicationsAgedDeliriumFemaleHumansIncidenceInfusions, IntravenousMaleMiddle AgedProspective StudiesSodiumSodiumHyponatremiaPostoperative deliriumPostoperative intravenous maintenance fluidSodium concentration

Identifiers

PMID41251707

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.