Evidence map›Paper›PMID 41251695›Full record

ArticlePediatric radiology2026

The apparent diffusion coefficient as a potential radiological biomarker of malignant transformation in retinoblastoma: a case report.

Sonia De Francesco, Paolo Galluzzi, Tommaso Padula, Giovanni Rubegni, Pierluigi De Marzo, Mario Fruschelli, Doris Hadjistilianou

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sonia De FrancescoDepartment of Medicine, Surgery and Neuroscience, Unit of Ophthalmology Ocular Oncology - Retinoblastoma Referral Center, Azienda Ospedaliera Universitaria Senese, Viale Bracci 1, 53100, Siena, Italy. defrancesco75@libero.it.
Paolo GalluzziDepartment of Neuroimaging and Neurointervention, Siena University Hospital, Viale Bracci 1, 53100, Siena, Italy.
Tommaso PadulaOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy. tommasopadula0498@gmail.com.
Giovanni RubegniOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy. giovannirubegni@gmail.com.
Pierluigi De MarzoOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy. pierluigidemarzo97@gmail.com.
Mario FruschelliOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy. mario.fruschelli@unisi.it.
Doris HadjistilianouDepartment of Medicine, Surgery and Neuroscience, Unit of Ophthalmology Ocular Oncology - Retinoblastoma Referral Center, Azienda Ospedaliera Universitaria Senese, Viale Bracci 1, 53100, Siena, Italy. dorisocularoncology@libero.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a unique case of malignant transformation in a retinocytoma monitored using magnetic resonance imaging (MRI). This case is notable for a distinct drop in apparent diffusion coefficient (ADC) values that correlated with clinical transformation to retinoblastoma. This is the first report to highlight a change in ADC as a radiological marker of malignant conversion in retinocytoma. This finding suggests the potential role of ADC in prognostic assessment and risk stratification for patients with retinocytoma.

Indexed as

Cell Transformation, NeoplasticDiffusion Magnetic Resonance ImagingRetinal NeoplasmsRetinoblastomaFemaleHumansInfantMaleAmblyopiaEsotropiaInfantMagnetic resonance imagingOphthalmoscopyRetinoblastoma

Identifiers

PMID41251695
PMCPMC12881030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.