Evidence map›Paper›PMID 41251693›Full record

ArticlePediatric radiology2026

Balancing radiation dose and image quality in infants on photon-counting CT for pediatric cardiac imaging: comparing 70 kV and 120 kV protocols.

Nolan H Dang, Wei Zhou, Gladys M Arguello Fletes, Jason P Weinman, LaDonna J Malone

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nolan H DangUniversity of Colorado Anschutz Medical Campus, Aurora, United States.
Wei ZhouUniversity of Colorado Anschutz Medical Campus, Aurora, United States.
Gladys M Arguello FletesDepartment of Radiology, University of Colorado Anschutz Medical Campus, 13123 E 16th Ave, B125, Aurora, CO, 80045, United States.
Jason P WeinmanDepartment of Radiology, University of Colorado Anschutz Medical Campus, 13123 E 16th Ave, B125, Aurora, CO, 80045, United States.
LaDonna J MaloneDepartment of Radiology, University of Colorado Anschutz Medical Campus, 13123 E 16th Ave, B125, Aurora, CO, 80045, United States. ladonna.malone@childrenscolorado.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhoton-counting CT (PCCT) has the potential to improve diagnosis and reduce radiation exposure in pediatric congenital heart disease. Early data in pediatric patients has shown advantages of advanced post-processing techniques that are currently only available with high kilovolt (kV) protocols.

objectiveThe purpose of our study was to compare image quality and radiation dose for low kV (70) and high kV (120) protocols in patients weighing under 10 kg.

methodsIn this IRB-approved retrospective review of ultra-high pitch cardiac CT scans in patients under 10 kg, we evaluated two protocols on a PCCT scanner: low kV (70) and high kV (120). Patient demographics, contrast-to-noise ratio in aorta and pulmonary artery, and subjective image quality scores using a 5-point Likert scale were evaluated by two readers in addition to radiation dose comparison.

resultsFifty-eight scans were included, 28 in the 70 kV cohort and 30 in the 120 kV cohort. Median age was 0.17 years for 70 kV and 0.33 years for 120 kV and weight was 4.5 kg for 70 kV and 5.4 kg for 120 kV. Contrast-to-noise ratios (aorta 14.8 vs 17.8, P=0.6) and Likert scores for aorta (median 5 for both groups, P=0.2) were similar for both protocols. Radiation dose was significantly lower in the 70 kV group with CTDI of 0.13 mGy vs 0.25 mGy for 120 kV (P<0.001).

conclusionA 70 kV protocol shows promise for reducing radiation dose in infants with similar image quality compared to the 120 kV protocol, although advanced spectral reconstructions would not be available.

Indexed as

Heart Defects, CongenitalRadiation DosageTomography, X-Ray ComputedFemaleHumansInfantInfant, NewbornMalePhotonsRetrospective StudiesComputed tomography angiographyCongenital heart defects: pediatricsPhoton-counting CTRadiation dose

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.