Evidence map›Paper›PMID 41251668›Full record

ArticleeLife2025

Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth.

Dengjin Li, Hai Zheng, Yang Bai, Zheng Zhang, Hao Cheng, Xiongliang Huang, Ting Wei, Matthew Chang, Arieh Zaritsky, Terence Hwa and 1 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dengjin Li *Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0009-0001-4148-5476
Hai Zheng *Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-7561-2269
Yang Bai *Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0001-9976-2686
Zheng ZhangKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-7824-211X
Hao ChengKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.
Xiongliang HuangKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.
Ting WeiKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-2926-5849
Matthew ChangNUS Synthetic Biology for Clinical and Technological Innovation and Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore; National Centre for Engineering Biology, Singapore, Singapore.
Arieh ZaritskyFaculty of Natural Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
Terence HwaDepartment of Physics & Department of Molecular Biology, University of California at San Diego, San Diego, United States.ORCID https://orcid.org/0000-0003-1837-6842
Chenli LiuKey Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Beijing, China.ORCID https://orcid.org/0000-0003-3029-7207

Funding

Chinese Academy of Sciences Strategic Priority Research Program of the Chinese Academy of Sciences XDB0480000Chinese Academy of Sciences Youth Innovation Promotion Association of the Chinese Academy of Sciences 2022369Israel Science Foundation Israel Science Foundation-NSFC joint research program 3320/20Israel Science Foundation Joint NSFC-ISF Research Grant 32061143021National Centre for Engineering Biology NRF-MSG-2023-0003National Key Research and Development Program of China 2021YFA0910703National Key Research and Development Program of China 2024YFA0916403National Natural Science Foundation of China 32025022National Natural Science Foundation of China 32170042National Natural Science Foundation of China 32230062National Natural Science Foundation of China Israel Science Foundation-NSFC joint research program 3320/20National Natural Science Foundation of China Joint NSFC-ISF Research Grant 32061143021National University of Singapore NUHSRO/2024/064/NUSMed/05/ SynCTI2.0United States-Israel Binational Science Foundation 2017004
6 · The paper itself

Abstract

Robust control of DNA replication is fundamental to bacterial proliferation. In

Indexed as

Bacterial ProteinsBiomassDNA-Binding ProteinsDNA ReplicationEscherichia coliEscherichia coli ProteinsDNA, BacterialGene Expression Regulation, BacterialBacterial ProteinsDnaA protein, BacteriaDNA, BacterialDNA-Binding ProteinsEscherichia coli Proteinsbacterial cell cyclebiomass-DNA coordinationcell biologychromosome replication initiationcomputational biologyDnaA activity oscillationsE. colisystems biology

Identifiers

PMID41251668
PMCPMC12626423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.