ArticleTranslational vision science & technology2025
Three-Dimensional Choroidal Contour Mapping in Central Serous Chorioretinopathy and Fellow Eyes.
Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Quantitative evaluation of three-dimensional (3D) choroidal contour at choroidal inner boundary (CIB) and choroidal outer boundary (COB) in central serous chorioretinopathy (CSCR) and fellow eyes of patients with unilateral CSCR. Methods: Retrospective study on 58 eyes of 29 patients with unilateral CSCR. Detailed examination and investigations including wide-field swept source optical coherence tomography (SS-OCT) were performed. Delineation of CIB and COB was performed using a hybrid method based on our previously validated deep learning and 3D smoothing methods for choroidal layer segmentation. Quantitative analysis of the surfaces was based on best-fit spherical radius (R). Statistical analysis was done using SPSS software. Results: R CIB and R COB was significantly higher in CSCR eyes compared to fellow eyes (P = 0.001, 0.02). On sectoral analysis, central sector had the lowest R compared to all the other sectors in CSCR eyes (P < 0.001) and fellow eyes (P < 0.001). Within the group, R CIB > R COB in CSCR eyes (P = 0.001) and in fellow eyes (P = 0.014), and there was a high degree of correlation between RCIB and RCOB within a group (CSCR: r = 0.88, P < 0.001; fellow eyes: r = 0.87, P < 0.001). Conclusions: This study shows CIB and COB to be flatter in CSCR eyes compared to fellow eyes. In both CSCR and fellow eyes, CIB is flatter than COB. Translational Relevance: Studying choroidal surfaces helps understand how predispositions and compensatory mechanisms to venous overloading may differ in CSCR and fellow eyes and how contour changes may serve as a biomarker for the disease.
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