ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Macrophages Mediate Mesoscale Brain Mechanical Homeostasis.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Age dependent collective trafficking of tissue resident T cells in zebrafish.bioRxiv : the preprint server for biology · 2026Article
- Macrophages Mediate Mesoscale Brain Mechanical Homeostasis.Advanced materials (Deerfield Beach, Fla.) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Mechanical cues orchestrate cellular behavior in the brain, yet how they interface with immune regulation remains unresolved. Here, gigahertz-frequency Brillouin microscopy with optical trap-based active microrheology is integrated to map the mechanical impact of macrophage activity across timescales. It is revealed that microglia, brain's resident macrophages, actively sustain tissue viscoelasticity, rather than quiescently residing within the tissues under normal conditions. Moreover, macrophage colony-stimulating factor 1 receptor (csf1r)-driven stromal remodeling alters brain mechanical properties in vivo. These findings establish a direct link between immune activity, viscoelastic integrity, and structural plasticity of neural tissue. By bridging high-frequency material responses with immune-driven remodeling, the approach provides a framework for decoding how biophysical properties regulate slower-timescale signaling and offers mechanistic insights for increasing the efficacy of csf1r-targeted therapies in cancer and neurodegeneration.
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Registered trials
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