Evidence map›Paper›PMID 41251492›Full record

ArticleMicrobiology spectrum2026

Impact of synonymous mutations in the

Rinku Dhungana, Heba Kaadan, Aparna Paudel, Peter Oelschlaeger

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecular Characterization of Colistin ResistanceAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Adaptive microevolution in CC17Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rinku DhunganaDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.ORCID 0009-0006-3035-3116
Heba KaadanDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.ORCID 0009-0000-5283-7396
Aparna PaudelDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.ORCID 0000-0003-0160-7296
Peter OelschlaegerDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA.ORCID 0000-0001-5949-9297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synonymous mutations (SMs) have a significant effect on the expression of the β-lactamase TEM-3 and the resistance phenotype conferred. Cell-free transcription did not reproduce this effect. The amount of mRNA obtained was identical for

Indexed as

beta-LactamasesEscherichia coliGene Expression Regulation, BacterialGenetic FitnessSilent MutationAnti-Bacterial AgentsCeftazidimeEscherichia coli ProteinsAnti-Bacterial Agentsbeta-LactamasesCeftazidimeEscherichia coli Proteinsantibiotic resistancebeta-lactamasegene deletiongene expressionsynonymous mutation

Identifiers

PMID41251492
PMCPMC12772226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.