ArticleBiomacromolecules2025
Green Synthesis of a Hyaluronan-Based Multimeric A9 Peptide System: Polysaccharide-A9 Conjugate with Enhanced HER2 Receptor Binding Affinity and Potential Biomedical Applications as an Active Material.
Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A solid-state strategy for conjugating the peptide sequence A9 to hyaluronic acid (HA) has been developed via mechanosynthesis promoted by microwave radiation. The method employs a silica-supported nucleophilic catalyst (DMAP) to activate the carboxylic groups of the polysaccharide, enabling efficient conjugation. These conditions minimize waste generation, enhancing environmental sustainability and operator safety while ensuring a high yield of the final HA-A9 conjugate. The multicopy HA-A9 system exhibits enhanced affinity toward a synthetic HER2 receptor model. Furthermore, the HA-A9 conjugate demonstrates the ability to self-assemble into micellar aggregates and form viscous materials enriched with β-sheet peptide structures. These supramolecular assemblies highlight the potential of conjugates for biomedical applications.
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