Evidence map›Paper›PMID 41251371›Full record

ArticleAntimicrobial agents and chemotherapy2025

Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials in

Rachel L Darnell, Melanie K Knottenbelt, Olivia E Rose, Caitlin S B Cleary, Francesca O Todd Rose, Hannah Hodgkinson, Yuezhou Wu, Maytham Hussein, Tony Velkov, Susanne Gebhard and 1 more

Abstract read
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In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachel L Darnell *Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID 0000-0002-2046-262X
Melanie K Knottenbelt *Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Olivia E RoseMilner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom.
Caitlin S B ClearyDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Francesca O Todd RoseDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Hannah HodgkinsonDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Yuezhou WuDepartment of Pharmacology, Monash Biodiscovery Institute, Monash University, Melbourne, Australia.
Maytham HusseinDepartment of Pharmacology, Monash Biodiscovery Institute, Monash University, Melbourne, Australia.ORCID 0000-0001-5922-7312
Tony VelkovDepartment of Pharmacology, Monash Biodiscovery Institute, Monash University, Melbourne, Australia.
Susanne GebhardMilner Centre for Evolution, Department of Life Sciences, University of Bath, Bath, United Kingdom.
Gregory M CookDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.ORCID 0000-0001-8349-1500

Funding

Health Research Council of New Zealand 20/213Maurice Wilkins Centre for Molecular Biodiscovery MWC307University of Otago Masters ScholarshipUniversity of Otago Research Grant
6 · The paper itself

Abstract

Antimicrobial tolerance, i.e., the ability to survive despite growth inhibition, is an important precursor to the development of antimicrobial resistance. However, very little is known about the evolution of drug-induced antimicrobial tolerance. Teixobactin (TXB) is an antimicrobial peptide that targets the cell envelope precursors lipid II and lipid III in Gram-positive bacteria. We have previously shown that

Indexed as

Anti-Bacterial AgentsCell WallDepsipeptidesEnterococcus faecalisBacterial ProteinsDrug Resistance, BacterialGene Expression Regulation, BacterialMicrobial Sensitivity TestsMutationAnti-Bacterial AgentsBacterial ProteinsDepsipeptidesteixobactinantibiotic tolerancecell envelope stress responsecell wall targetingcross-toleranceenterococcal polysaccharide antigenEnterococcusLiaFSRmevalonate pathwayresistance

Identifiers

PMID41251371
PMCPMC12691584

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.