Evidence map›Paper›PMID 41251351›Full record

ArticleJournal of virology2025

Pathogenesis of Hazara orthonairovirus infection in type I interferon receptor-deficient mice and resolution of disease following 4'-fluorouridine therapy.

Justin S Murray, Jonna B Westover, Dionna Scharton, Arnaud J Van Wettere, Alexander A Kolykhalov, Shuli Mao, Michael G Natchus, George R Painter, Brian B Gowen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Justin S MurrayDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.ORCID 0009-0007-9428-3337
Jonna B WestoverDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.
Dionna SchartonDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.
Arnaud J Van WettereDepartment of Veterinary and Clinical Life Sciences, Utah State University, Logan, Utah, USA.
Alexander A KolykhalovEmory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Shuli MaoEmory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Michael G NatchusEmory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
George R PainterEmory Institute for Drug Development, Emory University, Atlanta, Georgia, USA.
Brian B GowenDepartment of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA.ORCID 0000-0001-9113-2575

Funding

Task B6: In Vitro Assessment for Antimicrobial Activity Against Respiratory Viruses, Including SARS-CoV-275N93019D00021 · NIAID · UTAH STATE UNIVERSITY · PI JULANDER, JUSTIN · 2019 to 2025
$7.3M
NIAID NIH HHS 75N93019D00021NIAID NIH HHS HHSN272201700041I
6 · The paper itself

Abstract

The Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a widespread tick-borne agent that causes severe disease in humans. Its expanding geographic range poses a significant public health threat. Although animal models for CCHFV infection have been developed, the requirement for maximum biosafety level 4 facilities limits the development of countermeasures against the virus. Hazara virus (HAZV) is a closely related orthonairovirus that can be handled in biosafety level 2 containment and has been proposed as a prototype virus for the IMPORTANCE: The Crimean-Congo hemorrhagic fever orthonairovirus poses a significant public health threat, underscored by the expansion of

Indexed as

Hemorrhagic Fever, CrimeanNairovirusReceptor, Interferon alpha-betaAnimalsAntiviral AgentsDisease Models, AnimalFemaleHemorrhagic Fever Virus, Crimean-CongoHumansMiceMice, Inbred C57BLMice, KnockoutAntiviral AgentsReceptor, Interferon alpha-betaanimal modelsbroad-spectrum antiviralCrimean-Congo hemorrhagic fever virusHazara virusnairovirus

Identifiers

PMID41251351
PMCPMC12724280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.