The Administration of Melatonin Improved Depressive Behavior in Both Maximal Electroshock Seizure-Prone and Non-Seizure Mice After Undergoing Levetiracetam Treatment.

Objectives: Comorbid psychiatric disorders, especially depression, pose challenges in epilepsy. Antiepileptic drugs, including levetiracetam, can also have psychiatric adverse effects, necessitating strategies to address mood regulation. The study aims to assess the impact of melatonin administration on depressive behavior in epileptic and non-epileptic mice. Materials and Methods: Male albino mice were assigned to different treatment groups. Levetiracetam (20 mg/kg ip) was injected for 14 days; melatonin (25 mg/kg ip) was injected for 7 days. Additional groups were included for epileptic mice. Maximal electroshock was used to induce seizures: locomotor activity, immobility time in the forced swimming test (FST), latency, and food consumption were measured in the novelty-suppressed feeding test (NSFT). Results: There were insignificant differences in locomotor activity between groups. In the FST, levetiracetam administration significantly increased the immobility duration compared to the control group in epileptic and non-epileptic mice ( Conclusion: Melatonin was found to reduce depressive behavior in both non-epileptic and epileptic groups. These results suggest that melatonin could be a potential therapeutic agent for countering the depressive effects of levetiracetam.