Observational studyClinical transplantation2025
Correlation Between Health Literacy and Tacrolimus Variability in Solid Organ Transplant Recipients.
Observational study in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Correlation Between Health Literacy and Tacrolimus Variability in Solid Organ Transplant Recipients.Clinical transplantation · 2025Observational
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdherence to immunosuppressive therapy is crucial for successful outcomes in solid organ transplantation. Tacrolimus intra-patient variability (%CV) is a validated marker of adherence and has been associated with graft outcomes. Health literacy (HL), a modifiable factor, may influence this variability, but its role remains unexplored.
methodsWe conducted a prospective observational study including adult kidney, liver, and lung transplant recipients receiving tacrolimus. HL was assessed using the Short Test of Functional Health Literacy in Adults (S-TOFHLA); a score <23 indicated insufficient HL. Tacrolimus %CV was calculated over 6 months post-discharge. Linear regression models, adjusted for sociodemographic variables, evaluated the association between HL and %CV.
resultsNinety-eight patients were included (kidney: n = 38, liver: n = 24, lung: n = 36). Patients with insufficient HL had higher %CV than those with sufficient HL (31.5% vs. 16.1%, p < 0.05). HL remained independently associated with %CV after adjusting for age and transplant type (β = -1.60, SE = 0.17, p < 0.05). The final model explained 53% of %CV variability.
conclusionsHL is independently associated with tacrolimus variability. HL screening and targeted educational interventions may help improve medication stability and long-term transplant outcomes.
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