ReviewAdvanced healthcare materials2026
Harnessing Advances in Bone Tissue Engineering for Design of Bone-on-Chip Systems.
Review in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Vascularized bone organoids: current advances and a biomimetic platform for osteonecrosis of the femoral head.Bone research · 2026Review
- Harnessing Advances in Bone Tissue Engineering for Design of Bone-on-Chip Systems.Advanced healthcare materials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Organ-on-Chip systems demonstrate significant potential as next-generation models to study human (patho)physiology and to assess new therapies. Whereas on-chip models of soft tissues and organs have progressed substantially over the past decade, the development of bone-on-chip (BoC) systems remains comparatively slower. This slower progress stems from the structural and functional complexity of bone tissue, which hampers efforts to recapitulate bone (patho)physiology on-chip. Advances in bone tissue engineering (BTE) now provide opportunities regarding i) innovative biomaterials design strategies and ii) advanced bioengineering tools, enabling a closer replication of the architectural and functional complexity of native bone. However, these technological advances have primarily resulted in improved regenerative therapies, while also offering opportunities for innovative BoC designs. This perspective article identifies key requirements for BoCs, explores existing models and their respective advantages and limitations. Subsequently, opportunities derived from BTE are highlighted to accelerate the development of BoCs which more accurately capture crucial features of in vivo bone (patho)physiology. Finally, key considerations for BoC design are discussed, and an outlook for further developments in this emerging field is provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.