Evidence map›Paper›PMID 41251182›Full record

ArticleNucleic acids research2026

scGeneBank: cross-species screening of functional gene sets at single-cell resolution.

Siying Qin, Yuexi Yang, Lingmin Peng, Linlin Xu, Yushan Deng, Haoyu Wang, Xiwen Qiu, Yuanqing He, Xiangdong Wang, Yuting Ma and 2 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Computational modelling of cell identity.The Biochemical journal · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Siying QinState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Yuexi YangState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Lingmin PengState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Linlin XuState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Yushan DengState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Haoyu WangState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Xiwen QiuState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Yuanqing HeState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Xiangdong WangZhongshan Hospital, Department of Pulmonary and Critical Care Medicine, Institute for Clinical Science, Shanghai Institute of Clinical Bioinformatics, Shanghai 200032, China.
Yuting MaNational Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Li HuangState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.
Dongsheng ChenState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou 215123, Jiangsu, China.ORCID 0000-0002-7196-4136

Funding

CAMSChinese Academy of Medical Sciences 2022-RC416-01National Key Research and Development Program of China 2024YFC3607500National Natural Science Foundation of China 32300560Natural Science Foundation of Jiangsu Province BK20220279Peking Union Medical College 3332024089
6 · The paper itself

Abstract

Single-cell transcriptomics is reshaping the study of cellular physiology and pathology by revealing fine-grained cell functions and states. Interpreting these signals across cell types, organs, and species benefits from curated gene sets and tools for comparative analysis. Here, we introduce scGeneBank (http://8.142.154.29/scGeneBank or http://www.genebank.info), a database and analysis portal for gene set-driven exploration at single-cell resolution. The resource integrates 1134 carefully selected single-cell transcriptome datasets, totaling 104.9 million cells from 136 species and covering 430 organs and 1070 anatomical areas. It supports interactive analysis and visualization of 597 expert-curated gene sets organized into 28 biologically meaningful categories. Eight linked modules address common use cases: GeneSets (curated gene-set navigation), Species (dataset-level exploration), EvoScreening (cross-species comparisons within organs), OrganScreening (gene-set activity analysis across 35 human organs at cell-type resolution), StemAtlas (stemness profiling across species and organs), AgingScope (aging-related pathway analysis), PathoView (disease-associated gene expression analysis), and DeathMap (cell-death pathway activity visualization). Together, these modules provide a unified framework for comparing gene-set activity across species, organs, and cell types, enabling systematic studies of development, evolution, aging, disease, and cell death.

Indexed as

Databases, GeneticSingle-Cell AnalysisTranscriptomeAnimalsGene Expression ProfilingHumansOrgan SpecificitySoftwareSpecies Specificity

Identifiers

PMID41251182
PMCPMC12807785

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.