Evidence map›Paper›PMID 41251170›Full record

ArticleNucleic acids research2026

GeneFamily: a comprehensive mammalian gene family database with extensive annotation and interactive visualization.

Yinan Wang, Yuanzheng Zhang, Xueying Wang, Yen Kaow Ng, Yi Jia, Zicheng Zhao, Jiahe Liu, Shuo Yang, Bairong Shen, Shuai Cheng Li

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinan WangInstitutes for Systems Genetics, West China Hospital, Sichuan University, 24 South Section 1, Yihuan Road, Chengdu 610065, China.ORCID 0000-0001-5409-504X
Yuanzheng ZhangShenzhen Research Institute, City University of Hong Kong, 8 Yue Xing Yi Road, Nanshan District, Shenzhen 518057, China.
Xueying WangShenzhen Research Institute, City University of Hong Kong, 8 Yue Xing Yi Road, Nanshan District, Shenzhen 518057, China.ORCID 0000-0001-8979-3737
Yen Kaow NgOmicLab Limited, Unit 917, 19 Science Park West Avenue, New Territories, Hong Kong.
Yi JiaOmicLab Limited, Unit 917, 19 Science Park West Avenue, New Territories, Hong Kong.
Zicheng ZhaoOmicLab Limited, Unit 917, 19 Science Park West Avenue, New Territories, Hong Kong.
Jiahe LiuSchool of Creative Media, City University of Hong Kong, 83 Tat Chee Ave, Kowloon Tong, Hong Kong.
Shuo YangShenzhen Research Institute, City University of Hong Kong, 8 Yue Xing Yi Road, Nanshan District, Shenzhen 518057, China.
Bairong ShenInstitutes for Systems Genetics, West China Hospital, Sichuan University, 24 South Section 1, Yihuan Road, Chengdu 610065, China.ORCID 0000-0003-2899-1531
Shuai Cheng LiShenzhen Research Institute, City University of Hong Kong, 8 Yue Xing Yi Road, Nanshan District, Shenzhen 518057, China.ORCID 0000-0001-6246-6349

Funding

National Natural Science Foundation of China 32270690Shenzhen Science and Technology Program JCYJ20220818101201004
6 · The paper itself

Abstract

Gene families underlie genetic innovation and phenotypic diversification. However, the identification, analysis, and interpretation of gene families depend on custom bioinformatics and visualization workflows that are mainly unattainable for nonexpert users. To overcome the learning curve associated with analytical tools and the time costs involved in data collection and processing, we propose GeneFamily (https://gh.deepomics.org/), a comprehensive mammalian gene family database that incorporates extensive annotations and interactive visualizations. Leveraging whole-genome data from 138 mammalian species and Pfam-A hidden Markov models, GeneFamily encompasses 2036 gene families. Users can explore gene family distributions, phylogenetic trees, member diversities, sequence identities, structural features, conserved motifs, chromosomal localizations, neighboring regions, gene collinearities, duplication events, and adaptive signatures via an intuitive web interface. GeneFamily reduces technical barriers and accelerates research into gene family evolution, functional diversification, and comparative genomics across mammals.

Indexed as

Databases, GeneticMammalsMolecular Sequence AnnotationMultigene FamilySoftwareAnimalsComputational BiologyGenomeGenomicsHumansInternetPhylogenyUser-Computer Interface

Identifiers

PMID41251170
PMCPMC12807644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.