Evidence map›Paper›PMID 41251162›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Enantioconvergent Access to Chiral S(VI) Stereocenters by Kinetic Resolution of Sulfonimidoyl Chlorides.

Arko Das, Shree Krishna Dhakal, Ramon Trevino, Seth O Fremin, Vy T B Nguyen, Arka Porey, Sachchida Nand, Chandan Kumar Giri, Daniel J Wherritt, Hadi D Arman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals.Journal of the American Chemical Society · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arko Das *Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Shree Krishna Dhakal *Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Ramon Trevino *Department of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Seth O FreminDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Vy T B NguyenDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Arka PoreyDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Sachchida NandDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Chandan Kumar GiriDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Daniel J WherrittDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Hadi D ArmanDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.
Oleg V LarionovDepartment of Chemistry, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA.ORCID https://orcid.org/0000-0002-3026-1135

Funding

New organosulfur-based strategies for efficient construction of carbon-carbon and carbon-heteroatom bondsR35GM152123 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI Oleg V Larionov · 2024 to 2026
$1.1M
NIGMS NIH HHS GM152123NIGMS NIH HHS R35 GM152123
6 · The paper itself

Abstract

Sulfur chirality has recently gained in importance across a wide range of chemical domains. However, the dearth of catalytic approaches for sulfur(VI) stereocenters continues to present a challenge for the broader utilization of chiral-at-sulfur motifs. We report herein the development of a previously unexplored approach for the kinetic resolution of chiral sulfur(VI) functionalities that leverages the electrophilic reactivity of sulfur(VI) stereocenters. This catalytic strategy provides enantioconvergent access to sulfonimidoyl chlorides and sulfonimidates, which are some of the least explored and catalytically accessible stereogenic S(VI) functionalities. This study also elucidates the key roles of noncovalent interactions and highlights the importance of the unfunctionalized backbone of the catalyst in imparting high enantioselectivity to the kinetic resolution of heteroatom stereocenters.

Indexed as

Asymmetric catalysisKinetic resolutionSulfonimidatesSulfonimidoyl chloridesSulfur chirality

Identifiers

PMID41251162
PMCPMC12790358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.