Evidence map›Paper›PMID 41251150›Full record

ArticleNucleic acids research2026

The Reactome Knowledgebase 2026.

Eliot Ragueneau, Chuqiao Gong, Pierre Sinquin, Cristoffer Sevilla, Deidre Beavers, Alexander Grentner, Johannes Griss, Gregory F J Hogue, Nancy T Li, Lisa Matthews and 15 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Mapping Gene Expression to an Interpretable Semantic Space.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Eliot RagueneauEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID 0000-0002-7876-6503
Chuqiao GongEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Pierre SinquinEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Cristoffer SevillaEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Deidre BeaversDivision of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, United States.
Alexander GrentnerEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Johannes GrissEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Gregory F J HogueOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Nancy T LiOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Lisa MatthewsNYU Grossman School of Medicine, New York University, New York, NY 10016, United States.
Bruce MayOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Marija MilacicOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.ORCID 0000-0002-3218-5631
Helia MohammadiOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Robert PetryszakDivision of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, United States.
Karen RothfelsOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Veronica ShamovskyNYU Grossman School of Medicine, New York University, New York, NY 10016, United States.
Ralf StephanOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Krishna TiwariEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
Joel WeiserOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Adam WrightOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Marc GillespieOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Guanming WuDivision of Oncological Sciences, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239, United States.
Lincoln SteinOntario Institute for Cancer Research, Toronto, ON M5G0A3, Canada.
Henning HermjakobEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.ORCID 0000-0001-8479-0262
Peter D'EustachioNYU Grossman School of Medicine, New York University, New York, NY 10016, United States.ORCID 0000-0002-5494-626X

Funding

Reactome: An Open Knowledgebase of Human Pathways.U24HG012198 · NHGRI · ONTARIO INSTITUTE FOR CANCER RESEARCH · PI Marc E Gillespie, LINCOLN D. STEIN · 2022 to 2026
$7.0M
Reactome and the Gene Ontology: Digital pathway convergence for core data resourcesU24HG011851 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DEUSTACHIO, PETER G, MUNGALL, CHRISTOPHER J · 2021 to 2025
$3.6M
Connected Minds PrototypingEuropean Bioinformatics InstituteNHGRI NIH HHS U24 HG011851NHGRI NIH HHS U24 HG012198NIH HHS U24HG011851NIH HHS U24HG012198NIH HHS U24HG012198-02S1Open Targets
6 · The paper itself

Abstract

The Reactome Knowledgebase (https://reactome.org) is a freely accessible, expert-curated, open-source, and open-data resource that describes human biology in molecular detail. It spans normal physiology as well as disease mechanisms, including the impact of genetic variation and drug action. Reactome content is continuously expanded and revised, with automated workflows now monitoring retracted publications to maintain data integrity. To meet the needs of a growing user base, Reactome has launched a redesigned Angular-based interface with enhanced accessibility, modular architecture, and a hierarchy of visualization tools: ReacFoam for global pathway overviews, enhanced high-level diagrams for intuitive navigation, and redesigned entity level views (ELVs) enriched with chemical structures, animated protein models, and a new "compare mode" to contrast normal and disease states. New analysis tools support multi-omics integration and customizable visualizations. Recent innovations include the React-to-me chatbot for natural language interaction, community-driven tutorials, and an open Figma icon library. Reactome's sustainability and compliance with FAIR data principles were recently recognized with CoreTrustSeal certification and its designation as a Global Core Biodata and ELIXIR resource, reinforcing its role as a trusted global knowledgebase.

Indexed as

Knowledge BasesHumansInternetProteinsSoftwareUser-Computer InterfaceProteins

Identifiers

PMID41251150
PMCPMC12807730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.